The Department of International Health and Development, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Qual Life Res. 2012 Nov;21(9):1655-63. doi: 10.1007/s11136-011-0075-5. Epub 2011 Dec 25.
Summary scores derived from the medical outcomes study HIV health survey (MOS-HIV) are used to assess treatment impacts among HIV-infected patients in Western settings, but have yet to be validated in rural, African settings. We examined the reliability, validity and responsiveness of scores among a prospective cohort of 947 HIV-1-infected adults initiating antiretroviral therapy between May 2003 and May 2004 in rural Uganda.
Physical (PHS) and mental health (MHS) summary scores were developed from baseline MOS-HIV sub-domains using exploratory factor analysis. Construct and discriminant validity were established by comparing mean summary scores across known groups of sociodemographic, clinical and health status characteristics. Effect sizes were calculated to assess responsiveness to therapy.
Reliability of the PHS and MHS scores was 0.79 and 0.85, respectively. Mean baseline PHS and MHS scores varied significantly by CD4 cell count, HIV viral load, WHO stage of disease and Karnofsky performance status scores. By 12 months on antiretroviral therapy, PHS and MHS scores improved by 14.6 points (P < 0.001) and 13.9 points (P < 0.001), respectively.
PHS and MHS scores can be derived from the MOS-HIV and used to assess health status among cohorts of patients taking antiretroviral therapy in rural Uganda.
来自医学结局研究艾滋病毒健康调查（MOS-HIV）的综合评分用于评估西方环境中感染艾滋病毒患者的治疗效果，但尚未在农村非洲环境中得到验证。我们在乌干达农村地区对 947 名于 2003 年 5 月至 2004 年 5 月间开始接受抗逆转录病毒治疗的 HIV-1 感染成人进行了前瞻性队列研究，以评估评分的可靠性、有效性和反应性。
使用探索性因子分析，从 MOS-HIV 子域的基线中得出生理（PHS）和心理健康（MHS）综合评分。通过比较社会人口统计学、临床和健康状况特征的已知组别的平均综合评分来确定结构和判别有效性。计算效应大小以评估对治疗的反应性。
PHS 和 MHS 评分的可靠性分别为 0.79 和 0.85。CD4 细胞计数、HIV 病毒载量、疾病的世界卫生组织分期和卡诺夫斯基表现状态评分的基线平均 PHS 和 MHS 评分差异显著。在接受抗逆转录病毒治疗 12 个月后，PHS 和 MHS 评分分别提高了 14.6 分（P < 0.001）和 13.9 分（P < 0.001）。
可以从 MOS-HIV 中得出 PHS 和 MHS 评分，并用于评估在乌干达农村接受抗逆转录病毒治疗的患者队列的健康状况。
