Sherson D, Svane O, Lynge E
Department of Occupational Medicine Vejle Sygehus, Denmark.
Arch Environ Health. 1991 Mar-Apr;46(2):75-81. doi: 10.1080/00039896.1991.9937432.
Cancer incidence was studied among 6,144 male foundry workers who were invited to participate in either of two Danish national silicosis surveys conducted during 1967-1969 and 1972-1974. Cancer incidence was followed through to the end of 1985 by computerized linkage to the Danish Cancer Registry, and Standardized Morbidity Ratios (SMRs) were calculated based on incidence rates for the Danish population. For the entire cohort, significantly elevated SMRs were seen for all cancers (SMR, 1.09; 95% CI, 1.01-1.18) and lung cancer (SMR, 1.30; 95% CI, 1.12-1.51), and SMRs were at the borderline of statistical significance for bladder cancer (SMR, 1.24; 95% CI, 0.97-1.59). Excess lung and bladder cancer risk were confined to workers who had worked in foundries for at least 20 y. There was a positive correlation between silicosis prevalence in employees at the foundries at the time of the x-ray examinations and lung cancer incidence during the follow-up period. Squamous cell carcinomas, anaplastic carcinomas, and other lung cancers accounted for the excess lung cancer risk, whereas there was not excess risk among the foundry workers for adenocarcinomas of the lung.
对6144名男性铸造工人的癌症发病率进行了研究，这些工人受邀参加了1967 - 1969年和1972 - 1974年期间丹麦进行的两项全国矽肺病调查中的任意一项。通过与丹麦癌症登记处的计算机化链接，跟踪癌症发病率至1985年底，并根据丹麦人群的发病率计算标准化发病比（SMR）。对于整个队列，所有癌症（SMR，1.09；95%置信区间，1.01 - 1.18）和肺癌（SMR，1.30；95%置信区间，1.12 - 1.51）的SMR显著升高，膀胱癌的SMR处于统计学显著性边缘（SMR，1.24；95%置信区间，0.97 - 1.59）。肺癌和膀胱癌的超额风险仅限于在铸造厂工作至少20年的工人。在X光检查时铸造厂员工的矽肺病患病率与随访期间的肺癌发病率之间存在正相关。鳞状细胞癌、间变性癌和其他肺癌构成了肺癌的超额风险，而铸造厂工人中肺癌腺癌不存在超额风险。
