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聚醚醚酮椎间融合器作为治疗颈椎椎间盘炎的一种潜在替代方法:一组患者的初步报告

PEEK cages as a potential alternative in the treatment of cervical spondylodiscitis: a preliminary report on a patient series.

机构信息

Department of Neurosurgery, Medical Center of Friedrich-Schiller-University, Erlanger Allee 101, 07747, Jena, Germany.

出版信息

Eur Spine J. 2010 Jun;19(6):1004-9. doi: 10.1007/s00586-009-1265-5. Epub 2010 Jan 13.

Abstract

The surgical management of cervical spondylodiscitis consists of the resection of the affected disc, the decompression of the cervical spinal cord, followed by the stabilization using an autologous bone graft or a titanium implant combined with a ventral plate fixation. Until now, there were no studies about the practicability and putative safety of PEEK cages in cervical spine infection. Now, we present the history of five patients suffering from neurological deficits and septicemia caused by mono- or bisegmental pyogenic cervical discitis and intraspinal abscess without severe bone destruction. Patients were treated surgically by discectomy, decompression, and ventral spondylodesis. The disc was replaced by a PEEK cage without additional fixation. Progressive bony fusion and complete regression of the inflammatory changes was demonstrated 7-8 months later by a computer assisted tomography and contrast enhanced magnetic resonance imaging, respectively. The vertebral alignment changed minimally; the cages developed only a slight average subsidence. The clinical symptoms improved in all patients significantly. Neck pain or instability was never observed. Nevertheless, prospective investigations of a larger patient series are mandatory. We suppose that the use of PEEK cages represents a potential and safe alternative in the treatment of cervical spondylodiscitis in selected patients.

摘要

颈椎椎间盘炎的手术治疗包括切除受累椎间盘、减压颈脊髓,然后使用自体骨移植或钛植入物联合前路钢板固定进行稳定。到目前为止,尚无关于聚醚醚酮(PEEK)椎间融合器在颈椎感染中的实用性和假定安全性的研究。现在,我们介绍5例因单节段或双节段化脓性颈椎椎间盘炎和椎管内脓肿导致神经功能缺损和败血症且无严重骨质破坏的患者的病史。患者接受了椎间盘切除术、减压术和前路椎体融合术。椎间盘被PEEK椎间融合器替代,无需额外固定。7 - 8个月后,计算机断层扫描和对比增强磁共振成像分别显示了渐进性骨融合和炎症变化的完全消退。椎体排列变化极小;椎间融合器仅出现轻微的平均下沉。所有患者的临床症状均有显著改善。从未观察到颈部疼痛或不稳定。然而,必须对更大的患者系列进行前瞻性研究。我们认为,在选定的患者中,使用PEEK椎间融合器是治疗颈椎椎间盘炎的一种潜在且安全的替代方法。

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