State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
J Mater Sci Mater Med. 2010 Apr;21(4):1169-73. doi: 10.1007/s10856-010-3985-9. Epub 2010 Jan 13.
Willemite (Zn(2)SiO(4)) ceramics were prepared by sintering the willemite green compacts. The effects of sintering temperature on the linear shrinkage, porosity and mechanical strength of the ceramics were examined. With the sintering temperature increased, the linear shrinkage of the ceramics increased and the porosity decreased. When sintered at 1,300 degrees C, willemite ceramics showed mechanical properties of the same order of magnitude as values for human cortical bone, as measured by bending strength (91.2 +/- 4.2 MPa) and Young's modulus (37.5 +/- 1.5 GPa). In addition, the adhesion and proliferation of rabbit bone marrow stromal cells (BMSCs) on willemite ceramics was investigated. The results showed that the ceramics supported cell adhesion and stimulated the proliferation. All these findings suggest that willemite ceramics possess suitable mechanical properties and favorable biocompatibility and might be a promising biomaterial for bone implant applications.
锌硅灰石（Zn(2)SiO(4))陶瓷是通过烧结锌硅灰石生坯制备的。研究了烧结温度对陶瓷的线收缩率、孔隙率和机械强度的影响。随着烧结温度的升高，陶瓷的线收缩率增加，孔隙率降低。当在 1300°C 烧结时，锌硅灰石陶瓷的弯曲强度（91.2 ± 4.2 MPa）和杨氏模量（37.5 ± 1.5 GPa）等机械性能与人类皮质骨相当。此外，还研究了兔骨髓基质细胞（BMSCs）在锌硅灰石陶瓷上的黏附和增殖情况。结果表明，陶瓷支持细胞黏附和刺激细胞增殖。所有这些发现表明，锌硅灰石陶瓷具有合适的机械性能和良好的生物相容性，可能是一种有前途的骨植入材料。
