Storey Kenneth B, Storey Janet M
Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada, K1S 5B6.
Prog Mol Subcell Biol. 2010;49:25-45. doi: 10.1007/978-3-642-02421-4_2.
The biochemical regulation of aestivation, a state of aerobic hypometabolism, achieves actions including strong overall suppression of metabolic rate, reprioritization of energy use by diverse cell functions, and enhancement of defenses such as protein chaperones and antioxidants that aid long-term life extension. This is accomplished by mechanisms that include differential action of intracellular signaling cascades, reversible protein phosphorylation to alter the activity states of multiple enzymes and functional proteins, global suppression of transcription and translation, and selective gene upregulation. Recent advances in understanding the regulation of aestivation are discussed with a particular emphasis on land snail and anuran models.
夏眠是一种有氧低代谢状态，其生化调节实现了多种作用，包括全面强力抑制代谢率、重新分配不同细胞功能的能量利用，以及增强蛋白质伴侣和抗氧化剂等有助于延长寿命的防御机制。这是通过多种机制实现的，包括细胞内信号级联的差异作用、可逆的蛋白质磷酸化以改变多种酶和功能蛋白的活性状态、全面抑制转录和翻译，以及选择性基因上调。本文讨论了在理解夏眠调节方面的最新进展，特别强调了陆地蜗牛和无尾两栖类动物模型。
