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父方饮酒会影响大鼠后代的修饰反应。

Paternal alcohol consumption affects grooming response in rat offspring.

作者信息

Abel E L

机构信息

Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI.

出版信息

Alcohol. 1991 Jan-Feb;8(1):21-3. doi: 10.1016/0741-8329(91)91168-2.

DOI:10.1016/0741-8329(91)91168-2
PMID:2006980
Abstract

Grooming behavior in response to novelty and water immersion was examined in rat offspring sired by males consuming liquid alcohol diets containing 35%, 17.5% or 0% ethanol-derived calories (EDC). In the first study, offspring were tested at 35-38 days of age under conditions of lights on or off. Offspring in the 35% EDC group groomed less than controls. Lighting conditions did not affect grooming significantly. In the second study, animals were immersed in a water bath for 15 seconds and were then placed in the same observation chambers. As in the previous study, animals sired by alcohol-consuming fathers groomed considerably less than controls. These results were interpreted as suggesting offspring sired by alcohol-consuming fathers have a blunted response to conditions which spontaneously elicit behavior like grooming or ambulation.

摘要

对饮用含35%、17.5%或0%乙醇衍生热量(EDC)液体酒精饮食的雄性大鼠所产子代的新奇感和水浸反应的梳理行为进行了研究。在第一项研究中,子代在35 - 38日龄时在光照或黑暗条件下接受测试。35% EDC组的子代梳理行为少于对照组。光照条件对梳理行为没有显著影响。在第二项研究中,动物被浸入水浴中15秒,然后被放置在相同的观察室中。与前一项研究一样,由饮酒的父亲所生的动物梳理行为明显少于对照组。这些结果被解释为表明由饮酒的父亲所生的子代对自发引发梳理或行走等行为的条件反应迟钝。

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