超重和肥胖的伴胰岛素抵抗的土耳其患者血管紧张素转换酶基因多态性。

Angiotensin-converting enzyme gene polymorphism in overweight and obese Turkish patients with insulin resistance.

机构信息

Department of Endocrinology and Metabolism, Faculty of Medicine, Pamukkale University, Denizli, Turkey.

出版信息

DNA Cell Biol. 2010 Apr;29(4):207-12. doi: 10.1089/dna.2009.0934.

DOI:10.1089/dna.2009.0934

PMID:20070157

Abstract

The aim of this study was to analyze the distribution of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in obese Turkish patients with insulin resistance (IR). Sixty-two obese Turkish patients with IR were enrolled in this study. One hundred healthy people without IR were recruited as the control group. ACE amplification was performed by polymerase chain reaction. The frequency of the DD genotype was significantly higher in obese patients with IR than in control subjects. Of sixty-two patients, 1 (1.6%) had an II genotype, 22 (35.5%) had an ID genotype, and 39 (62.9%) had a DD genotype. The frequency of the I allele in the patient group was significantly lower than in controls. We found that the frequency of the DD genotype was higher in obese Turkish patients with IR. ACE gene I/D polymorphism may be associated with obesity in the Turkish population.

摘要

本研究旨在分析血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性在肥胖伴胰岛素抵抗（IR）的土耳其患者中的分布。本研究纳入了 62 例肥胖伴 IR 的土耳其患者。100 名无 IR 的健康人作为对照组。通过聚合酶链反应（PCR）进行 ACE 扩增。IR 肥胖患者的 DD 基因型频率明显高于对照组。在 62 例患者中，1 例（1.6%）为 II 基因型，22 例（35.5%）为 ID 基因型，39 例（62.9%）为 DD 基因型。患者组 I 等位基因的频率明显低于对照组。我们发现，IR 肥胖土耳其患者的 DD 基因型频率较高。ACE 基因 I/D 多态性可能与土耳其人群的肥胖有关。