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经口鼻吸入的微米颗粒。

Inhalability of micron particles through the nose and mouth.

机构信息

School of Aerospace, Mechanical and Manufacturing Engineering, RMIT University, Bundoora, Victoria, Australia.

出版信息

Inhal Toxicol. 2010 Mar;22(4):287-300. doi: 10.3109/08958370903295204.

Abstract

Aspiration efficiencies from nose and mouth inhalations are investigated at low and high inhalation rates by using the commercial Computational Fluid Dynamics (CFD) software CFX 11. A realistic human head with detailed facial features was constructed. Facial features were matched to represent the 50th percentile of a human male, aged between 20 and 65 years old, based on anthropometric data. The constant freestream velocity was 0.2 ms(-1), normal to the face, and inhalation rates through the mouth and nose were 15 liters per minute (LPM) for light breathing and 40 LPM for heavy breathing. It was found that the flow field in the near breathing region exhibited vertical direction caused by the presence of the torso where the airstream diverges as it flows around and over the body. The critical area concept was used as a tool to determine the aspiration efficiency of particles. Comparisons between critical areas for the nose and mouth inhalations show similar geometric properties such as the area's shape, and its vertical distance location on the x-z plane located at y = 80 cm upstream. The critical area sizes were found to be slightly larger for the mouth inhalation mainly due to the larger mouth area and also the aligned orientation of the mouth to the upstream flow, whereas the nose is perpendicular to the upstream flow. This study was undertaken to establish the flow field in the near breathing region that will help to characterize the flow and particle field for initial boundary conditions leading to a more holistic modeling approach of respiration through the internal nasal cavity and mouth.

摘要

通过使用商业计算流体动力学(CFD)软件 CFX 11,研究了在低和高吸入率下通过口鼻吸入的吸气效率。构建了一个具有详细面部特征的逼真的人头模型。根据人体测量数据,面部特征进行了匹配,以代表 20 至 65 岁之间的 50 百分位男性。恒定的主流速度为 0.2 ms(-1),垂直于面部,通过口鼻的吸入率分别为 15 升/分钟(LPM)用于轻呼吸和 40 LPM 用于重呼吸。结果发现,近呼吸区域的流场呈现出垂直方向,这是由于躯干的存在造成的,空气流在流过和绕过身体时会发生分流。临界区域概念被用作确定颗粒吸气效率的工具。口鼻吸入的临界区域之间的比较显示出相似的几何特性,例如区域的形状及其在 x-z 平面上位于 y = 80 cm 上游的垂直距离位置。发现口腔吸入的临界区域尺寸略大,主要是由于口腔面积较大,以及口腔与上游流对齐的方向,而鼻子则垂直于上游流。这项研究旨在建立近呼吸区域的流场,这将有助于描述流动和颗粒场,为通过内部鼻腔和口腔进行呼吸的更整体建模方法提供初始边界条件。

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