Clinical Microbiology Unit, Regional Reference Centre for Microbiological Emergencies-CRREM, St. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.
Euro Surveill. 2009 Dec 17;14(50):19448.
We report a case of Usutu virus (USUV)-related illness in a patient that underwent an orthotropic liver transplant (OLT). Post transplant, the patient developed clinical signs of a possible neuroinvasive disease with a significant loss of cerebral functions. USUV was isolated in Vero E6 cells from a plasma sample obtained immediately before the surgery, and USUV RNA was demonstrated by RT-PCR and sequencing. This report enlarges the panel of emerging mosquito-borne flavivirus-related disease in humans.
我们报告了一例乌苏图病毒（USUV）相关疾病的病例，该患者接受了同种异体肝移植（OLT）。移植后，患者出现了可能的神经侵袭性疾病的临床症状，并出现了严重的脑功能丧失。从手术前获得的血浆样本中，在 Vero E6 细胞中分离出 USUV，通过 RT-PCR 和测序证实存在 USUV RNA。本报告扩大了人类新兴蚊媒黄病毒相关疾病的范围。
