2009 年 8 月-9 月，意大利首例乌苏图病毒神经侵袭感染的人类病例。
First human case of Usutu virus neuroinvasive infection, Italy, August-September 2009.
机构信息
Department of Diagnostic and Laboratory Services and Legal Medicine, University of Modena and Reggio Emilia, Azienda Ospedaliera Policlinico, Modena, Italy.
出版信息
Euro Surveill. 2009 Dec 17;14(50):19446.
We report the first worldwide case of Usutu virus (USUV) neuroinvasive infection in a patient with diffuse large B cell lymphoma who presented with fever and neurological symptoms and was diagnosed with meningoencephalitits. The cerebrospinal fluid was positive for USUV, and USUV was also demonstrated in serum and plasma samples by RT-PCR and sequencing. Partial sequences of the premembrane and NS5 regions of the viral genome were similar to the USUV Vienna and Budapest isolates.
我们报告了首例乌苏图病毒（USUV）引起的神经侵袭性感染病例，该患者患有弥漫性大 B 细胞淋巴瘤，表现出发热和神经症状，并被诊断为脑膜脑炎。脑脊液中检测到 USUV，RT-PCR 和测序也证实血清和血浆样本中存在 USUV。病毒基因组的前膜和 NS5 区域的部分序列与 USUV 维也纳和布达佩斯分离株相似。
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