p21 激活激酶（Paks）在病毒感染中的新作用。
An emerging role for p21-activated kinases (Paks) in viral infections.
机构信息
Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
出版信息
Trends Cell Biol. 2010 Mar;20(3):160-9. doi: 10.1016/j.tcb.2009.12.005. Epub 2010 Jan 12.
Abstract
p21-activated protein kinases (Paks) are cytosolic serine/threonine protein kinases that act as effectors for small (p21) GTPases of the Cdc42 and Rac families. It has long been established that Paks play a major role in a host of vital cellular functions such as proliferation, survival and motility, and abnormal Pak function is associated with a number of human diseases. Here, we discuss emerging evidence that these enzymes also play a major role in the entry, replication and spread of many important pathogenic human viruses, including HIV. Careful assessment of the potential role of Paks in antiviral immunity will be pivotal to evaluate thoroughly the potential of agents that inhibit Pak as a new class of anti-viral therapeutics.
摘要
p21 激活蛋白激酶（Paks）是细胞溶质丝氨酸/苏氨酸蛋白激酶，作为 Cdc42 和 Rac 家族的小（p21）GTPases 的效应物发挥作用。长期以来，人们已经确定 Paks 在许多重要的细胞功能中发挥着主要作用，例如增殖、存活和迁移，并且异常的 Pak 功能与许多人类疾病有关。在这里，我们讨论了新出现的证据，表明这些酶也在许多重要的致病性人类病毒（包括 HIV）的进入、复制和传播中发挥主要作用。仔细评估 Paks 在抗病毒免疫中的潜在作用对于全面评估抑制 Pak 的药物作为一类新型抗病毒治疗药物的潜力至关重要。
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