Service de Biologie du Développement et Médecine de la Reproduction, Centre Hospitalier Universitaire de Nantes, Nantes France.
Eur J Obstet Gynecol Reprod Biol. 2010 Apr;149(2):186-9. doi: 10.1016/j.ejogrb.2009.12.029. Epub 2010 Jan 13.
To study the potential of CASA parameters in frozen-thawed donor semen before and after preparation on silica gradient as predictors of pregnancy in IUI with donor semen cycles.
CASA parameters were measured in thawed donor semen before and after preparation on a silica gradient in 132 couples undergoing 168 IUI cycles with donor semen. The evolution of these parameters throughout this process was calculated. The relationship with cycle outcome was then studied.
Clinical pregnancy rate was 18.4% per cycle. CASA parameters on donor semen before or after preparation were not significantly different between pregnancy and failure groups. However, amplitude of lateral head displacement (ALH) of spermatozoa improved in all cycles where pregnancy occurred, thus predicting pregnancy with a sensitivity of 100% and a specificity of 20%.
Even if CASA parameters do not seem to predict pregnancy in IUI with donor semen cycles, their evolution during the preparation process should be evaluated, especially for ALH. However, the link between ALH improvement during preparation process and pregnancy remains to be explored.
研究在硅烷醇梯度上制备前后冷冻-解冻供体精液的 CASA 参数作为预测供体精液 IUI 周期妊娠的潜能。
对 132 对接受 168 个供体精液 IUI 周期的夫妇的解冻供体精液在硅烷醇梯度上制备前后进行 CASA 参数测量。计算整个过程中这些参数的变化。然后研究与周期结果的关系。
每个周期的临床妊娠率为 18.4%。妊娠组和失败组之间，供体精液制备前后的 CASA 参数没有显著差异。然而，所有妊娠发生的周期中，精子的侧向头部位移幅度（ALH）均有改善，因此其敏感性为 100%，特异性为 20%，可预测妊娠。
即使 CASA 参数似乎不能预测供体精液 IUI 周期的妊娠，但应评估其在制备过程中的变化，尤其是对于 ALH。然而，制备过程中 ALH 改善与妊娠之间的联系仍有待探索。
