Quantitation of fentanyl in blood and urine using gas chromatography-mass spectrometry (GC-MS).

作者信息

Goldberger Bruce A, Chronister Chris W, Merves Michele L

机构信息

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA.

出版信息

Methods Mol Biol. 2010;603:245-52. doi: 10.1007/978-1-60761-459-3_22.

DOI:10.1007/978-1-60761-459-3_22

PMID:20077075

Abstract

Fentanyl is a potent, short-acting synthetic opioid analgesic. Fentanyl is measured in blood and urine following mixed-mode solid phase extraction. The specimens are fortified with deuterated internal standard and a five-point calibration curve is constructed. The final extracts are reconstituted in methanol and analyzed using selected ion monitoring gas chromatography-mass spectrometry.

摘要