Key Lab of Inorganic Coating Materials, Shanghai Institute of Ceramics, CASS, Shanghai 200050, China.
J Am Chem Soc. 2010 Feb 10;132(5):1450-1. doi: 10.1021/ja907560y.
Here we report the design of a new external electric field-controlled release system using functional dipolar molecules as nanoimpellers. The dipolar molecule 4-(3-cyanophenyl)butylene, which can reorient in response to external electric fields with different frequencies because of its strong inherent dipole moment, was synthesized and grafted onto the inner surfaces of mesopores. Under an alternating electric field, the swinging flexible molecular chains consequently push guest molecules out of the pore voids. This innovative approach to controlled release may provide important application opportunities in tumor treatment with a number of advantages in terms of local release with targetability, external remote control, and the nonelectrochemical nature of the process.
在这里，我们报告了一种新的外部电场控制释放系统的设计，该系统使用功能偶极分子作为纳米推进器。偶极分子 4-(3-氰基苯基)丁烯由于其强烈的固有偶极矩，可以在外电场的不同频率下重新定向，它被合成并接枝到介孔的内表面上。在外加电场作用下，摆动的柔性分子链将客体分子推出孔穴。这种控制释放的创新方法可能为肿瘤治疗提供重要的应用机会，具有局部释放靶向性、外部远程控制和过程的非电化学性质等优点。
