Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Paediatr Perinat Epidemiol. 2010 Jan;24(1):93-101. doi: 10.1111/j.1365-3016.2009.01070.x.
Maternal diet and nutrition have been thought to play a role in many childhood conditions. Studies using food frequency questionnaires (FFQ) have reported associations with maternal diet, but these findings are difficult to interpret because the reliability and validity of the FFQs for diet during a past pregnancy are not known. We determined the reproducibility of reported diet and supplement use during a past pregnancy in a subset of mothers interviewed for a case-control study of maternal diet in relation to the risk of childhood brain tumours. Cases were Children's Oncology Group patients, diagnosed at age <6 with medulloblastoma or primitive neuroectodermal tumour from 1991 to 1997. Area code, race/ethnicity, and birth date matched controls were selected by random-digit-dialling. Case and control mothers completed a modified Willett FFQ a mean of 5 years after the index child's birth. A mean of 3.6 months later, a subset of mothers consisting of 52 case and 51 control mothers repeated the interview; these comprise the reproducibility study population. The mean intra-class correlation was 0.59 (range 0.41, 0.69) for energy-adjusted nutrients from dietary sources only; it was 0.41 (range 0.06, 0.70) when supplements were included. Agreement for reporting multivitamin use during pregnancy by time period and pattern was good to very good (kappa = 0.66-0.85). Overall, the reproducibility of nutrient estimates and supplement use in pregnancy was good and similar to that reported for adult diet.
母体饮食和营养被认为在许多儿童疾病中起作用。使用食物频率问卷 (FFQ) 的研究报告了与母体饮食的关联，但这些发现难以解释，因为过去妊娠期间 FFQ 对饮食的可靠性和有效性尚不清楚。我们在一项关于母体饮食与儿童脑瘤风险关系的病例对照研究中，对部分接受采访的母亲进行了过去妊娠期间报告的饮食和补充剂使用的可重复性研究。病例是儿童肿瘤学组的患者，1991 年至 1997 年间，年龄<6 岁，诊断为髓母细胞瘤或原始神经外胚层肿瘤。区号、种族/族裔和出生日期与通过随机数字拨号选择的对照组相匹配。病例和对照母亲在指数儿童出生后平均 5 年完成了改良的威利特 FFQ。大约 3.6 个月后，由 52 例病例和 51 例对照母亲组成的亚组重复了访谈；这些构成了可重复性研究人群。仅从饮食来源计算能量调整后的营养素的平均组内相关系数为 0.59（范围 0.41-0.69）；当包括补充剂时，其为 0.41（范围 0.06-0.70）。报告怀孕期间使用多种维生素的时间和模式的一致性为良好至非常好（kappa = 0.66-0.85）。总体而言，营养估计和妊娠期间补充剂使用的可重复性良好，与成人饮食的报告相似。
