Department of Microbiology and Immunology, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Nat Rev Drug Discov. 2010 Feb;9(2):117-28. doi: 10.1038/nrd3013. Epub 2010 Jan 18.
Antibiotic resistance is one of the greatest challenges of the twenty-first century. However, the increasing understanding of bacterial pathogenesis and intercellular communication has revealed many potential strategies to develop novel drugs to treat bacteria-mediated disease. Interference with bacterial virulence and/or cell-to-cell signalling pathways is an especially compelling approach, as it is thought to apply less selective pressure for the development of bacterial resistance than traditional strategies, which are aimed at killing bacteria or preventing their growth. Here, we discuss the mechanisms of bacterial virulence and present promising anti-virulence strategies and compounds for the future treatment of bacterial infections.
抗生素耐药性是 21 世纪面临的最大挑战之一。然而，对细菌发病机制和细胞间通讯的深入了解揭示了许多开发新型药物治疗细菌介导疾病的潜在策略。干扰细菌毒力和/或细胞间信号通路是一种特别有吸引力的方法，因为与旨在杀死细菌或阻止其生长的传统策略相比，它被认为对细菌耐药性的发展施加的选择性压力较小。在这里，我们讨论了细菌毒力的机制，并提出了有前途的抗毒力策略和化合物，用于未来治疗细菌感染。
