Department Primary Care, 229-HAG, General Practice/Women's Studies in Medicine, Radboud University Nijmegen Medical Center, PO Box 9101/117 HAG, 6500 HB, Nijmegen, The Netherlands.
Clin Rheumatol. 2010 Jun;29(6):575-82. doi: 10.1007/s10067-009-1362-1. Epub 2010 Jan 19.
Clinically, gout is generally considered as a preferential male disease. However, it definitely does not occur exclusively in males. Our aim was to assess differences in the clinical features of gout arthritis between female and male patients. Five electronic databases were searched to identify relevant original studies published between 1977 and 2007. The included studies had to focus on adult patients with primary gout arthritis and on sex differences in clinical features. Two reviewers independently assessed eligibility and quality of the studies. Out of 355 articles, 14 were selected. Nine fulfilled the quality and score criteria. We identified the following sex differences in the clinical features of gout in women compared to men: the onset of gout occurs at a higher age, more comorbidity with hypertension or renal insufficiency, more often use of diuretics, less likely to drink alcohol, less often podagra but more often involvement of other joints, less frequent recurrent attacks. We found interesting sex differences regarding the clinical features of patients with gout arthritis. To diagnose gout in women, knowledge of these differences is essential, and more research is needed to understand and explain the differences , especially in the general population.
临床上，痛风一般被认为是一种偏爱男性的疾病。然而，它肯定不仅仅发生在男性身上。我们的目的是评估男女痛风关节炎患者的临床特征差异。检索了五个电子数据库，以确定 1977 年至 2007 年期间发表的相关原始研究。纳入的研究必须专注于原发性痛风关节炎的成年患者，以及临床特征的性别差异。两位评审员独立评估了研究的合格性和质量。在 355 篇文章中，有 14 篇被选中。9 篇符合质量和评分标准。我们发现女性痛风的临床特征与男性相比存在以下性别差异：痛风发病年龄较高，合并高血压或肾功能不全的情况较多，利尿剂使用更频繁，饮酒较少，足痛风较少，但其他关节受累更常见，复发性发作较少。我们发现痛风关节炎患者的临床特征存在有趣的性别差异。为了在女性中诊断痛风，了解这些差异至关重要，需要进一步研究以理解和解释这些差异，特别是在普通人群中。
