蝾螈视网膜中无长突细胞和神经节细胞的反应及感受野

Responses and receptive fields of amacrine cells and ganglion cells in the salamander retina.

作者信息

Zhang Ai-Jun, Wu Samuel M

机构信息

Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030, USA.

出版信息

Vision Res. 2010 Mar 17;50(6):614-22. doi: 10.1016/j.visres.2010.01.009. Epub 2010 Jan 18.

DOI:10.1016/j.visres.2010.01.009

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3644516/

Abstract

Retinal amacrine cells (ACs) and ganglion cells (GCs) have been shown to display large morphological diversity, and here we show that four types of ACs and three types of GCs exhibit physiologically-distinguishable properties. They are the sustained ON ACs; sustained OFF ACs; transient ON-OFF ACs; transient ON-OFF ACs with wide receptive fields; sustained ON-center/OFF-surround GCs; sustained OFF-center/ON-surround GCs and transient ON-OFF GCs. By comparing response waveforms, receptive fields and relative rod/cone inputs of ACs and GCs with the corresponding parameters of various types of the presynaptic bipolar cells (BCs), we analyze how different types of BCs mediate synaptic inputs to various ACs and GCs. Although more types of third-order retinal neurons may be identified by more refined classification criteria, our observations suggest that many morphologically-distinct ACs and GCs share very similar physiological responses.

摘要

视网膜无长突细胞（ACs）和神经节细胞（GCs）已被证明具有很大的形态多样性，并且我们在此表明，四种类型的ACs和三种类型的GCs表现出生理上可区分的特性。它们是持续型ON-ACs；持续型OFF-ACs；瞬变型ON-OFF-ACs；具有宽感受野的瞬变型ON-OFF-ACs；持续型ON中心/OFF周边GCs；持续型OFF中心/ON周边GCs和瞬变型ON-OFF GCs。通过将ACs和GCs的反应波形、感受野以及相对视杆/视锥输入与各种类型的突触前双极细胞（BCs）的相应参数进行比较，我们分析了不同类型的BCs如何介导对各种ACs和GCs的突触输入。尽管通过更精细的分类标准可能会识别出更多类型的三级视网膜神经元，但我们的观察结果表明，许多形态上不同的ACs和GCs具有非常相似的生理反应。