Clinical Nutrition and Risk Factor Modification Centre, St Michael's Hospital, Toronto, Ontario, Canada.
Eur J Clin Nutr. 2010 Apr;64(4):436-8. doi: 10.1038/ejcn.2009.159. Epub 2010 Jan 20.
Despite strong correlations linking whole-grain consumption to reductions in heart disease, the physiological mechanisms involved remain ambiguous. We assessed whether Salba (Salvia Hispanica L.) whole grain reduces postprandial glycemia in healthy subjects, as a possible explanation for its cardioprotective effects observed in individuals with diabetes. The study used acute, randomized, double-blind, controlled design in which 11 healthy individuals (6 males and 5 females; body mass index 22.3+/-2.8 kg/m(2)) received 0, 7, 15 or 24 g of Salba baked into white bread. Capillary samples and appetite ratings were collected over 2 h after consumption. A dose-response reduction in postprandial glycemia (P=0.002, r(2)=0.203) was observed with all three doses of Salba, significantly decreasing incremental areas under the curve (iAUCs) and time point-specific blood glucose (P<0.05). Appetite ratings were decreased at 60 min after high, 90 min after high and intermediate and at 120 min after all treatments (P<0.05). Decrease in postprandial glycemia provides a potential explanation for improvements in blood pressure, coagulation and inflammatory markers previously observed after 12-week Salba supplementation in type II diabetes.
尽管全谷物的消费与心脏病风险的降低密切相关，但相关的生理机制仍不清楚。我们评估了 Salba（Salvia Hispanica L.）全谷物是否能降低健康受试者的餐后血糖，这可能是其在糖尿病患者中观察到的心脏保护作用的一个解释。该研究采用急性、随机、双盲、对照设计，11 名健康个体（6 名男性和 5 名女性；体重指数 22.3+/-2.8 kg/m(2)) 分别摄入 0、7、15 或 24 g 烤制的 Salba 白面包。在摄入后 2 小时内收集毛细血管样本和食欲评分。Salba 的三个剂量均观察到餐后血糖的剂量反应性降低（P=0.002，r(2)=0.203），显著降低了增量曲线下面积（iAUCs）和特定时间点的血糖（P<0.05）。高剂量组在 60 分钟、高剂量组和中剂量组在 90 分钟以及所有治疗组在 120 分钟后食欲评分降低（P<0.05）。餐后血糖的降低可能解释了此前在 II 型糖尿病患者中观察到的 12 周 Salba 补充后血压、凝血和炎症标志物的改善。
