Kamp-Becker Inge, Smidt Judith, Ghahreman Mardjan, Heinzel-Gutenbrunner Monika, Becker Katja, Remschmidt Helmut
Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps-University Marburg, Hans-Sachs-Strasse 6, Marburg, Germany.
J Autism Dev Disord. 2010 Aug;40(8):921-9. doi: 10.1007/s10803-010-0939-5.
There is an ongoing debate whether a differentiation of autistic subtypes, especially between Asperger Syndrome (AS) and high-functioning-autism (HFA) is possible and if so, whether it is a categorical or dimensional one. The aim of this study was to examine the possible clustering of responses in different symptom domains without making any assumption concerning diagnostic appreciation. About 140 children and adolescents, incorporating 52 with a diagnosis of AS, 44 with HFA, 8 with atypical autism and 36 with other diagnoses, were examined. Our study does not support the thesis that autistic disorders are discrete phenotypes. On the contrary, it provides evidence that e.g. AS and autism are not qualitatively distinct disorders, but rather different quantitative manifestations of the same disorder.
关于自闭症亚型，尤其是阿斯伯格综合征（AS）和高功能自闭症（HFA）之间是否可能存在区分，以及如果可以区分，这种区分是类别性的还是维度性的，目前仍在争论中。本研究的目的是在不做任何关于诊断评估假设的情况下，检查不同症状领域的反应可能存在的聚类情况。研究了约140名儿童和青少年，其中包括52名被诊断为AS的、44名被诊断为HFA的、8名被诊断为非典型自闭症的以及36名有其他诊断的。我们的研究不支持自闭症谱系障碍是离散表型的论点。相反，它提供了证据表明，例如AS和自闭症并非在性质上不同的障碍，而是同一障碍的不同数量表现形式。
