Grima Pierfrancesco, Guido Marcello, Zizza Antonella, Chiavaroli Roberto
Division of Infectious Diseases, HIV Center, "S. Caterina Novella" Hospital, Galatina, Italy.
J Clin Ultrasound. 2010 May;38(4):190-5. doi: 10.1002/jcu.20664.
The aim of our study was to evaluate whether perirenal fat thickness (PRFT), a parameter of central obesity, is related to carotid intima-media thickness (IMT), an index of atherosclerosis in human immunodeficiency virus (HIV)-1-infected patients.
We enrolled 70 consecutive HIV-1-infected patients receiving highly active antiretroviral therapy for more than 12 months, in a prospective cohort study. Sonographically measured PRFT and carotid IMT, as well as serum metabolic parameters, were evaluated. PRFT and IMT were measured using 3.75-MHz convex and 7.5-MHz linear probes, respectively.
The mean PRFT and IMT in HIV-1-infected patients with visceral obesity was significantly greater than those in patients without it (p < 0.0001 and p < 0.01, respectively). Using the average IMT as the dependent variable in regression analysis, PRFT was an independent factor associated with carotid IMT (p < 0.05). A PRFT of 6.4 mm was the most discriminatory value for predicting an IMT >or= 0.9 mm (sensitivity 83.3%, specificity 83.9%). Subjects with visceral obesity had a progressively increasing carotid IMT on the 12-month measurement (p < 0.05).
Our data demonstrated that PRFT measurement could be used as an early predictor of IMT increase in HIV-1-infected patients receiving highly active antiretroviral therapy.
我们研究的目的是评估作为中心性肥胖参数的肾周脂肪厚度（PRFT）是否与人类免疫缺陷病毒（HIV）-1感染患者动脉粥样硬化指标颈动脉内膜中层厚度（IMT）相关。
在一项前瞻性队列研究中，我们纳入了70例连续接受高效抗逆转录病毒治疗超过12个月的HIV-1感染患者。评估了超声测量的PRFT和颈动脉IMT以及血清代谢参数。PRFT和IMT分别使用3.75MHz凸阵探头和7.5MHz线阵探头测量。
内脏肥胖的HIV-1感染患者的平均PRFT和IMT显著高于无内脏肥胖的患者（分别为p<0.0001和p<0.01）。在回归分析中，以平均IMT作为因变量，PRFT是与颈动脉IMT相关的独立因素（p<0.05）。PRFT为6.4mm是预测IMT≥0.9mm的最具鉴别力的值（敏感性83.3%，特异性83.9%）。内脏肥胖的受试者在12个月测量时颈动脉IMT逐渐增加（p<0.05）。
我们的数据表明，PRFT测量可作为接受高效抗逆转录病毒治疗的HIV-1感染患者IMT增加的早期预测指标。
