School of Mechanical & Aerospace Engineering, Queen's University of Belfast, Belfast, Northern Ireland, UK.
J Mater Sci Mater Med. 2010 Aug;21(8):2299-305. doi: 10.1007/s10856-009-3977-9. Epub 2010 Jan 22.
Calcium phosphate cements have the potential to be successful in minimally invasive surgical techniques, like that of vertebroplasty, due to their ability to be injected into a specific bone cavity. These bone cements set to produce a material similar to that of the natural mineral component in bone. Due to the ceramic nature of these materials they are highly brittle and it has been found that they are difficult to inject. This study was carried out to determine the factors that have the greatest effect on the mechanical and handling properties of an apatitic calcium phosphate cement with the use of a Design of Experiments (DoE) approach. The properties of the cement were predominantly influenced by the liquid:powder ratio and weight percent of di-sodium hydrogen phosphate within the liquid phase. An optimum cement composition was hypothesised and tested. The mechanical properties of the optimised cement were within the clinical range for vertebroplasty, however, the handling properties still require improvement.
磷酸钙骨水泥具有在微创外科技术中取得成功的潜力，例如椎体成形术，因为它们能够被注入到特定的骨腔中。这些骨水泥凝固后会产生类似于天然矿物质成分的物质。由于这些材料具有陶瓷性质，它们非常脆，并且已经发现它们难以注射。本研究旨在使用实验设计（DoE）方法确定对具有磷灰石的磷酸钙骨水泥的机械和处理性能具有最大影响的因素。水泥的性能主要受液相中的液粉比和二水合磷酸氢二钠的重量百分比的影响。假设并测试了最佳的水泥组成。优化后的水泥的机械性能在经皮椎体成形术的临床范围内，但是，处理性能仍需提高。
