Tammela Liisa I, Pääkkönen Ari, Karhunen Leila J, Karhu Jari, Uusitupa Matti I J, Kuikka Jyrki T
Department of Clinical Nutrition, School of Public Health and Clinical Nutrition, University of Kuopio, and Kuopio University Hospital, Kuopio, Finland.
Clin Physiol Funct Imaging. 2010 Mar;30(2):135-40. doi: 10.1111/j.1475-097X.2009.00916.x. Epub 2010 Jan 20.
Binge-eating (BE) subjects have shown altered brain activity at frontal regions during food presentation. The aim of this study was to examine the frontal brain electrical activity in obese BE women (n = 12) and in obese women without BE (non-BE, n = 13). Brain electrical activity was measured using a quantitative electroencephalography during a resting state (eyes-closed) and when the subjects focused (eyes-open) their attention on a picture of a landscape (control experiment) or on a meal (food experiment). The BE showed greater frontal beta activity (14-20 Hz) than the non-BE in both the eyes-closed (on average 52%) and the eyes-open situations and independently of the stimulus (control experiment: 57% and food experiment: 71%). No significant differences between the groups were found in alpha, delta or theta amplitudes. Increased beta activity correlated positively with the disinhibition factor of the Three-Factor Eating Questionnaire. Thus, our results suggest that elevated frontal beta activity may be a marker of dysfunctional disinhibition-inhibition mechanism, which could make the obese BE women more vulnerable or sensitive to food and the environmental cues.
暴饮暴食（BE）受试者在看到食物时额叶区域的大脑活动出现了改变。本研究的目的是检测肥胖的BE女性（n = 12）和无BE的肥胖女性（非BE，n = 13）的额叶脑电活动。在静息状态（闭眼）以及受试者将注意力集中（睁眼）在一幅风景图片（对照实验）或一顿饭（食物实验）上时，使用定量脑电图测量脑电活动。在闭眼（平均52%）和睁眼情况下，无论刺激类型如何（对照实验：57%，食物实验：71%），BE组的额叶β活动（14 - 20赫兹）均高于非BE组。两组在α、δ或θ波幅上未发现显著差异。β活动增加与三因素饮食问卷的去抑制因子呈正相关。因此，我们的结果表明额叶β活动升高可能是功能失调的去抑制 - 抑制机制的一个标志，这可能使肥胖的BE女性对食物和环境线索更易受影响或更敏感。
