Servicio de Microbiología, Hospital Donostia, San Sebastián, Spain.
Epidemiol Infect. 2010 Sep;138(9):1235-41. doi: 10.1017/S095026881000004X. Epub 2010 Jan 25.
The incidence of hospitalization for acute gastroenteritis (AGE) is a useful parameter to assess the utility of the new rotavirus vaccines in high-income countries. Children hospitalized for AGE were identified by searching hospital discharge data and the records of the microbiology laboratory of Hospital Donostia. Rotavirus antigen was investigated in 96.1% of the 1114 children aged 1 month to <5 years hospitalized for AGE in the study period. Nearly 40% were rotavirus positive (44.9% of the 798 children aged 1 month to <2 years), with G1[P8] being the predominant genotype. The mean annual incidence rate of hospitalization due to rotavirus AGE was 29.8 and 63.7 cases/10 000 inhabitants in the <5 and <2 years age groups, respectively, in 1996-1999, decreasing to 13.6 and 27.4 cases/10 000 inhabitants in <5 and <2 years age groups, respectively, in 2002-2005 (P<0.001). This decrease coincided with a significant increase in the consumption of oral rehydration solutions.
急性肠胃炎（AGE）住院发病率是评估新轮状病毒疫苗在高收入国家实用性的一个有用参数。AGE 住院儿童通过搜索医院出院数据和 Hospital Donostia 微生物实验室的记录来确定。在研究期间，对 1114 名年龄在 1 个月至<5 岁因 AGE 住院的儿童中，96.1%的儿童检测了轮状病毒抗原。近 40%为轮状病毒阳性（798 名年龄在 1 个月至<2 岁的儿童中，阳性率为 44.9%），其中 G1[P8]为主要基因型。1996-1999 年，<5 岁和<2 岁年龄组因轮状病毒 AGE 住院的年发病率分别为 29.8 和 63.7 例/10000 居民，到 2002-2005 年，<5 岁和<2 岁年龄组分别降至 13.6 和 27.4 例/10000 居民（P<0.001）。这种下降与口服补液溶液使用量的显著增加相一致。
