Servicio de Microbiología, Hospital Universitario Donostia-Instituto BioDonostia, San Sebastián, Spain.
Epidemiol Infect. 2013 Apr;141(4):868-74. doi: 10.1017/S0950268812001306. Epub 2012 Jul 3.
Between July 2009 and June 2011, rotavirus was detected in 507 of 4597 episodes of acute gastroenteritis in children aged <3 years in Gipuzkoa (Basque Country, Spain), of which the G-type was determined in 458 (90·3%). During the annual seasonal epidemic of 2010-2011, the unusual G-type 12 was predominant, causing 65% (145/223) of cases of rotavirus gastroenteritis. All the G12 strains were clustered in lineage III and were preferentially associated with P-type 8. This epidemic was characterized by broad geographical distribution (rural and urban) and, over 7 months, affected both infants and children, the most frequently affected being children between 4 and 24 months. Of children with rotavirus G12, 16% required hospital admission, the admission rate in children aged <2 years being 20·7 cases/10 000 children. The sudden emergence and predominance of G12 rotaviruses documented in this winter outbreak suggest that they may soon become a major human rotavirus genotype.
在 2009 年 7 月至 2011 年 6 月期间，在西班牙巴斯克地区吉普斯夸省年龄<3 岁的儿童中，有 4597 例急性肠胃炎病例，其中有 507 例（90.3%）检测出轮状病毒。在 2010-2011 年的年度季节性流行期间，不常见的 G 型 12 是主要类型，导致 65%（145/223）的轮状病毒肠胃炎病例。所有 G12 株都聚集在 III 谱系中，并且与 P 型 8 优先相关。这次疫情的特点是广泛的地理分布（农村和城市），并且在 7 个月的时间里，影响了婴儿和儿童，受影响最严重的是 4 至 24 个月大的儿童。轮状病毒 G12 感染的儿童中有 16%需要住院治疗，年龄<2 岁的儿童的住院率为 20.7 例/10000 名儿童。在这次冬季暴发中记录到 G12 轮状病毒的突然出现和流行，表明它们可能很快成为一种主要的人类轮状病毒基因型。
