烟曲霉P型高尔基体Ca2+/Mn2+ ATP酶PmrA参与阳离子稳态和细胞壁完整性，但对致病性并非必需。
The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis.
作者信息
Pinchai Nadthanan, Juvvadi Praveen Rao, Fortwendel Jarrod R, Perfect B Zachary, Rogg Luise E, Asfaw Yohannes G, Steinbach William J
机构信息
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Eukaryot Cell. 2010 Mar;9(3):472-6. doi: 10.1128/EC.00378-09. Epub 2010 Jan 22.
Abstract
The Aspergillus fumigatus DeltapmrA (Golgi apparatus Ca(2+)/Mn(2+) P-type ATPase) strain has osmotically suppressible basal growth defects and cationic tolerance associated with increased expression of calcineurin pathway genes. Despite increased beta-glucan and chitin content, it is hypersensitive to cell wall inhibitors but remains virulent, suggesting a role for PmrA in cation homeostasis and cell wall integrity.
摘要
烟曲霉ΔpmrA（高尔基体Ca²⁺/Mn²⁺ P型ATP酶）菌株具有渗透压可抑制的基础生长缺陷以及与钙调神经磷酸酶途径基因表达增加相关的阳离子耐受性。尽管β-葡聚糖和几丁质含量增加，但它对细胞壁抑制剂高度敏感，但仍具有毒性，这表明PmrA在阳离子稳态和细胞壁完整性中发挥作用。
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