眼底自发荧光和光谱域光学相干断层扫描在羟氯喹黄斑病变早期检测中的应用
Fundus autofluorescence and spectral domain optical coherence tomography in early detection of Plaquenil maculopathy.
作者信息
Kelmenson Amy T, Brar Vikram S, Murthy Ravi K, Chalam Kakarla V
机构信息
Department of Ophthalmology, University of Florida College of Medicine, Jacksonville, FL 32209, USA.
出版信息
Eur J Ophthalmol. 2010 Jul-Aug;20(4):785-8. doi: 10.1177/112067211002000423.
PURPOSE
To report fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT) findings in a patient with early hydroxychloroquine maculopathy.
METHODS
A 50-year-old man presented with complaints of ring-like shadows in front of his eyes. He had been on hydroxychloroquine (Plaquenil) 400 mg orally twice daily for 10 years (5.14 mg/kg/day). Fundus examination revealed granular hypopigmentation in an arcuate pattern in the inferior parafoveal area bilaterally. The patient underwent further evaluation with SD-OCT and FAF imaging. Functional changes were assessed by microperimetry.
RESULTS
Hypopigmented lesions on the fundus were autofluorescent and SD-OCT corresponding to this area revealed loss of inner segment-outer segment, suggesting loss of photoreceptor layer in the affected area with underling dysfunctional retinal pigment epithelium.
CONCLUSIONS
Findings on SD-OCT and FAF imaging support the histopathologic findings described in cases of hydroxychloroquine maculopathy.
目的
报告1例早期羟氯喹黄斑病变患者的眼底自发荧光（FAF）和频域光学相干断层扫描（SD - OCT）检查结果。
方法
一名50岁男性主诉眼前有环状阴影。他口服羟氯喹（硫酸羟氯喹片）400毫克，每日两次，共10年（5.14毫克/千克/天）。眼底检查显示双侧黄斑下区域呈弓形颗粒状色素减退。患者接受了SD - OCT和FAF成像的进一步评估。通过微视野检查评估功能变化。
结果
眼底色素减退病变呈自发荧光，SD - OCT显示对应区域内节 - 外节缺失，提示受累区域光感受器层缺失及视网膜色素上皮功能障碍。
结论
SD - OCT和FAF成像结果支持羟氯喹黄斑病变病例中描述的组织病理学发现。
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