微视野检查在检测青少年系统性红斑狼疮患儿羟氯喹早期视网膜毒性中的价值

Value of Microperimetry in Detecting Early Retinal Toxicity of Hydroxychloroquine in Children with Juvenile Systemic Lupus Erythematosus.

作者信息

Youssef Maha M, El-Fayoumi Dina, Sidky Mohamed Karim, Hegazy Ahmed I, Marzouk Huda, Eltanamly Rasha M

机构信息

Ophthalmology and Pediatric Rheumatology Departments, Faculty of Medicine, Cairo University, Cairo, Egypt.

出版信息

Ophthalmologica. 2017;237(3):180-184. doi: 10.1159/000461595. Epub 2017 Mar 16.

DOI:10.1159/000461595

PMID:28297699

Abstract

PURPOSE

To evaluate retinal sensitivity in children who are on hydroxychloroquine (HCQ) for systemic lupus erythematosus using microperimetry and compare the results with those of the Humphrey visual field (HVF) 10-2 and spectral-domain optical coherence tomography (SD-OCT).

PROCEDURE

A case-control cross-sectional study including 19 patients (less than 18 years old) on HCQ for at least 5 years. Controls were 21 normal children. Participants underwent a complete ophthalmic examination, then were investigated using HVF 10-2, SD-OCT, and microperimetry.

RESULTS

Ocular examination revealed no abnormalities. The overall mean microperimetry sensitivity of the patients (15.75 dB) was not significantly different from that of the controls (16.35 dB). The HVF 10-2 showed a significant difference in the mean deviation of the patients. Conclusions and Message: Microperimetry was not more revealing than HVF 10-2 and SD-OCT. Larger studies are required to compare the diagnostic accuracy of screening modalities of retinal toxicity in children on HCQ.

摘要

目的

使用微视野计评估因系统性红斑狼疮而服用羟氯喹（HCQ）的儿童的视网膜敏感度，并将结果与 Humphrey 视野计（HVF）10 - 2 和光谱域光学相干断层扫描（SD - OCT）的结果进行比较。

程序

一项病例对照横断面研究，纳入 19 名（年龄小于 18 岁）服用 HCQ 至少 5 年的患者。对照组为 21 名正常儿童。参与者接受了全面的眼科检查，然后使用 HVF 10 - 2、SD - OCT 和微视野计进行检查。

结果

眼部检查未发现异常。患者的微视野计总体平均敏感度（15.75 dB）与对照组（16.35 dB）无显著差异。HVF 10 - 2 显示患者的平均偏差有显著差异。结论与启示：微视野计在揭示视网膜毒性方面并不比 HVF 10 - 2 和 SD - OCT 更具优势。需要开展更大规模的研究来比较 HCQ 治疗儿童视网膜毒性筛查方式的诊断准确性。