Research Center of Modernization of Chinese Medicines, Central South University, Changsha, China.
Planta Med. 2010 Dec;76(17):1997-2003. doi: 10.1055/s-0030-1250541. Epub 2010 Nov 9.
The holistic system of traditional Chinese medicine (TCM) is an integrity of the ingredients contained in the Chinese herbal medicines, which creates a challenge in establishing quality control standards for raw materials and the standardization of finished herbal drugs because no single component is contributing to the total efficacy. Chromatographic fingerprinting analysis represents a rational approach for the quality assessment of TCM. It utilizes chromatographic techniques, which include CE, GC, HPLC, HPTLC, etc., to construct specific patterns for recognition of multiple compounds in TCMs. Thus, chromatographic fingerprinting analysis of herbal medicines represents a comprehensive qualitative approach for the purpose of species authentication, evaluation of quality, and ensuring the consistency and stability of herbal drugs and their related products. The pragmatic comprehensive chromatographic fingerprinting analysis can disclose the detectable ingredients composition and concentration distribution under quantifiable operational conditions and therefore provide real-time quality information. It may leave a "gray" entity at the primary stage. However, consecutive study will deepen the knowledge and reduce its "gray scale", increase the transparency gradually, thereby strengthening its quality assessment potency.
中医整体系统是中药中所含成分的整体，这给原材料的质量控制标准和草药成品的标准化带来了挑战，因为没有单一成分对总疗效有贡献。色谱指纹分析代表了中药质量评估的一种合理方法。它利用色谱技术，包括 CE、GC、HPLC、HPTLC 等，构建中药中多种化合物的特定模式识别。因此，草药的色谱指纹分析代表了一种综合的定性方法，用于物种鉴定、质量评估以及确保草药及其相关产品的一致性和稳定性。实用的综合色谱指纹分析可以在可量化的操作条件下揭示可检测成分的组成和浓度分布，从而提供实时质量信息。它可能在初始阶段留下一个“灰色”实体。然而，连续的研究将加深对其的认识，减少其“灰度”，逐渐增加透明度，从而增强其质量评估能力。
