Animal Ecophysiology Laboratory, Faculty of Sciences of Sfax, University of Sfax, Sfax, Tunisia.
Immunopharmacol Immunotoxicol. 2010 Sep;32(3):437-45. doi: 10.3109/08923970903490486.
Immunological disorders and nephropathy are among the most frequent and serious complications of diabetes mellitus. This shows that fewer infiltrated inflammatory cells evidenced by reverted back to near the normal value of white blood cell, mean corpuscular volume, and lymphocytes counts as interleukin-6 in pancreas. Also, fenugreek oil significantly improved blood glucose levels, glucose intolerance, and insulin sensitivity compared to the diabetic group. The pancreatic islet and less beta-cells damage were observed after the administration of fenugreek oil to diabetic rats. Moreover, diabetic rats showed low activities of superoxide dismutase, catalase, glutathione peroxidase, and reduced glutathione content in kidney, which were restored to near normal levels by treatment with fenugreek oil. The increased levels of lipid peroxidation, creatinine, albumin, and urea in diabetic rats decreased significantly in diabetic rats treated with fenugreek oil. Diabetic rats treated with fenugreek oil restored almost a normal architecture of pancreas and kidney. In conclusion, this study reveals the efficacy of fenugreek oil in the amelioration of diabetes, hematological status, and renal toxicity which may be attributed to its immunomodulatory activity and insulin stimulation action along with its antioxidant potential.
免疫紊乱和肾病是糖尿病最常见和最严重的并发症之一。这表明，白细胞、平均红细胞体积和淋巴细胞计数等炎症细胞浸润减少，白细胞介素-6（IL-6）在胰腺中的含量恢复到接近正常水平。此外，与糖尿病组相比，葫芦巴油显著降低了血糖水平、葡萄糖耐量和胰岛素敏感性。在给予糖尿病大鼠葫芦巴油后，观察到胰岛和较少的β细胞损伤。此外，糖尿病大鼠肾脏中超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和还原型谷胱甘肽含量降低，用葫芦巴油治疗可使其恢复接近正常水平。糖尿病大鼠的脂质过氧化产物、肌酐、白蛋白和尿素水平升高，经葫芦巴油治疗后显著降低。用葫芦巴油治疗的糖尿病大鼠的胰腺和肾脏结构几乎恢复正常。总之，本研究揭示了葫芦巴油在改善糖尿病、血液状况和肾毒性方面的功效，这可能与其免疫调节活性、胰岛素刺激作用以及抗氧化潜力有关。
