Khuri-Bulos Najwa, Williams John V, Shehabi Asem A, Faouri Samir, Al Jundi Ehsan, Abushariah Omar, Chen Qingxia, Ali S Asad, Vermund Sten, Halasa Natasha B
Department of Paediatrics and Pathology-Microbiology, Jordan University, Amman, Jordan.
Scand J Infect Dis. 2010 May;42(5):368-74. doi: 10.3109/00365540903496544.
Acute respiratory infections (ARI) play a major role in hospitalizations in the Middle East, but the specific viral causes are unknown. We conducted prospective viral surveillance in children <5 y of age admitted with ARI and/or fever at 2 dissimilar hospitals in Amman, Jordan during peak respiratory syncytial virus (RSV) season. We collected prospective clinical and demographic data and obtained nose/throat swabs for testing for RSV by real-time polymerase chain reaction (RT-PCR). We obtained clinical and laboratory data for 728/743 (98%) subjects enrolled. The children's median age was 4.3 months, 58.4% were males, 87% were breastfed, 4% attended day care, 67% were exposed to smokers, 7% were admitted to the intensive care unit, and 0.7% died (n = 5). Out of 728 subjects, 467 (64%) tested positive by RT-PCR for RSV. Comparing RSV-positive with RSV-negative subjects, the RSV-positive subjects had lower median age (3.6 vs 6.4 months, p < 0.001) and fewer males (55% vs 64%, p = 0.02). RSV-positive children had higher rates of oxygen use (72% vs 42%, p < 0.001), a longer hospital stay (5 vs 4 days, p = 0.001), and higher hospital charges (US$538 vs US$431, p < 0.001) than RSV-negative children. In young hospitalized Jordanian infants, the medical and financial burden of RSV was found to be high. Effective preventive measures, such as an RSV vaccine, would have a significant beneficial impact.
急性呼吸道感染（ARI）在中东地区的住院病例中占主要比例，但具体的病毒病因尚不清楚。在呼吸道合胞病毒（RSV）流行高峰季节，我们在约旦安曼市两家不同的医院，对因ARI和/或发热入院的5岁以下儿童进行了前瞻性病毒监测。我们收集了前瞻性临床和人口统计学数据，并采集鼻/咽拭子，通过实时聚合酶链反应（RT-PCR）检测RSV。我们获得了743名入组受试者中728名（98%）的临床和实验室数据。这些儿童的中位年龄为4.3个月，58.4%为男性，87%为母乳喂养，4%接受日托，67%接触吸烟者，7%入住重症监护病房，0.7%死亡（n = 5）。在728名受试者中，467名（64%）经RT-PCR检测RSV呈阳性。将RSV阳性与RSV阴性受试者进行比较，RSV阳性受试者的中位年龄较低（3.6个月对6.4个月，p < 0.001），男性较少（55%对64%，p = 0.02）。与RSV阴性儿童相比，RSV阳性儿童吸氧率更高（72%对42%，p < 0.001），住院时间更长（5天对4天，p = 0.001），住院费用更高（538美元对431美元，p < 0.001）。在约旦住院的幼儿中，发现RSV造成的医疗和经济负担很重。有效的预防措施，如RSV疫苗，将产生显著的有益影响。
