Abu-Helalah Munir, Al-Shatnawi Samah F, Abu Lubad Mohammad, Al-Zayadneh Enas, Jdaitawi Hussein, Harahsheh Mea'ad, Al-Iede Montaha, Nafi Omar, Yousef Ruba, Almaaitah Ihsan, Ababneh Mai, AlZubi Toqa, Mahfouz Rand Abu, Adaylah Heba, AlHajaj Hamzeh, Tamimi Mohammad Al, Drysdale Simon B
Department of Family and Community Medicine, Faculty of Medicine, Jordan University, Amman 11942, Jordan.
Public Health Institute, The University of Jordan, Amman 11942, Jordan.
Viruses. 2024 Nov 30;16(12):1867. doi: 10.3390/v16121867.
Respiratory syncytial virus (RSV) has been recognized as a highly important cause of morbidity and mortality among children and adults. A cross-sectional study at representative sites in Jordan was undertaken to provide an assessment of the epidemiology and health and economic burdens of RSV and influenza infections in Jordan amongst hospitalized children under 5 years old for the period between 15 November 2022 and 14 April 2023. This study involved 1000 patients with a mean age of 17.10 (SD: 16.57) months. Of these, half ( = 506, 50.6%) had positive results for RSV. Furthermore, 33% and 17.4% of the participants had positive results for RSV-B and RSV-A, respectively. The findings underscore the severity of RSV infections, where a significant proportion of the children experienced severe respiratory distress, which led to bronchiolitis and pneumonia. This study meticulously documented the clinical outcomes, including the need for intensive care, mechanical ventilation, and prolonged hospital stays. There was no statistically significant difference in the financial burdens between the RSV-positive and RSV-negative patients. This study revealed the urgent need for preventive measures to control the substantial burden of RSV among children under 5 years old in Jordan.
呼吸道合胞病毒（RSV）已被公认为儿童和成人发病和死亡的一个非常重要的原因。在约旦的代表性地点开展了一项横断面研究，以评估2022年11月15日至2023年4月14日期间约旦5岁以下住院儿童中RSV和流感感染的流行病学、健康和经济负担。本研究纳入了1000名患者，平均年龄为17.10（标准差：16.57）个月。其中，一半（n = 506，50.6%）的RSV检测结果呈阳性。此外，分别有33%和17.4%的参与者RSV-B和RSV-A检测结果呈阳性。研究结果强调了RSV感染的严重性，相当一部分儿童出现了严重的呼吸窘迫，进而导致细支气管炎和肺炎。本研究详细记录了临床结局，包括重症监护、机械通气的需求以及住院时间延长。RSV阳性和RSV阴性患者之间的经济负担没有统计学上的显著差异。本研究揭示了迫切需要采取预防措施来控制约旦5岁以下儿童中RSV造成的巨大负担。
