肺腺癌侵袭中的 TGF-β 信号通路。
Tgf-beta signaling pathway in lung adenocarcinoma invasion.
机构信息
Division of Pulmonary and Critical Care Medicine, Columbia University Medical Center, New York, NY, USA.
出版信息
J Thorac Oncol. 2010 Feb;5(2):153-7. doi: 10.1097/JTO.0b013e3181c8cc0c.
Abstract
The histologic distinction between bronchioloalveolar carcinoma and other adenocarcinomas is tissue invasion. The clinical importance of lung adenocarcinoma invasion is supported by several recent studies indicating that the risk of death in nonmucinous bronchioloalveolar carcinoma is significantly lower than that of pure invasive tumors and in tumors with greater than 0.5 cm of fibrosis or linear invasion. Using microarray gene expression profiling of human tumors, dysregulation of transforming growth factor-beta signaling was identified as an important mediator of tumor invasion. Subsequent studies showed that the CC chemokine regulated on activation, normal T cell expressed, and presumably secreted was up-regulated in invasive tumors and was required for invasion in cells with repressed levels of the transforming growth factor-beta type II receptor. Taken together, these studies illustrate how information gained from global expression profiling of tumors can be used to identify key pathways and genes mediating tumor growth, invasion, and metastasis.
摘要
肺腺癌组织学侵袭的临床重要性得到了几项近期研究的支持，这些研究表明，非黏液性细支气管肺泡癌的死亡风险明显低于单纯浸润性肿瘤和纤维化或线性浸润大于 0.5cm 的肿瘤。通过对人类肿瘤的基因表达谱进行微阵列分析，转化生长因子-β信号的失调被确定为肿瘤侵袭的重要介质。随后的研究表明，CC 趋化因子调节活化、正常 T 细胞表达和推测分泌在上皮性肿瘤中上调，并在转化生长因子-β II 型受体表达受抑制的细胞中促进侵袭。综上所述，这些研究说明了如何利用肿瘤的全基因组表达谱分析来鉴定肿瘤生长、侵袭和转移的关键途径和基因。
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