Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, 33 Queen Square, London, WC1N 3BG, UK.
MAGMA. 2010 Dec;23(5-6):309-16. doi: 10.1007/s10334-009-0196-9. Epub 2010 Jan 26.
The brain's activity can be measured in numerous complementary ways, including electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). The simultaneous acquisition of EEG and fMRI was originally developed to make the localization of the generators of often subtle pathological activity commonly observed in EEG recordings of patients with epilepsy more sensitive and spatially accurate by mapping their hemodynamic correlates. Now, the value of the information provided by simultaneous EEG-fMRI is being evaluated in a clinical context, while in parallel, more sophisticated data analysis techniques, e.g. with electrical source imaging or dynamic causal modeling, have begun to be applied to increase the technique's sensitivity and allow the study of brain network structure. Beyond its clinically oriented application in epilepsy, simultaneous EEG-fMRI recording has now gained interest as a tool for basic and systems human neuroscience, e.g. the study of neuro-vascular coupling and cognitive studies. In this review, we give an overview over the current use of simultaneous EEG-fMRI, its applications to the study of epilepsy as well as human cognition and systems neuroscience and ongoing and anticipated methodological developments.
大脑的活动可以通过多种互补的方式进行测量，包括脑电图（EEG）和功能磁共振成像（fMRI）。EEG 和 fMRI 的同步采集最初是为了通过绘制其血流动力学相关性来提高对癫痫患者 EEG 记录中常见的细微病理活动的发生器的定位的敏感性和空间准确性。现在，正在临床环境中评估同时进行 EEG-fMRI 提供的信息的价值，同时，更复杂的数据分析技术，例如电源成像或动态因果建模，已经开始应用于提高技术的敏感性并允许研究大脑网络结构。除了在癫痫方面的临床应用外，同步 EEG-fMRI 记录现在作为一种工具在基础和系统人类神经科学中引起了关注，例如神经血管耦合的研究和认知研究。在这篇综述中，我们概述了同时进行 EEG-fMRI 的当前用途、其在癫痫以及人类认知和系统神经科学研究中的应用，以及正在进行和预期的方法学发展。
