Cosentino G, Giglia G, Palermo A, Panetta M L, Lo Baido R, Brighina F, Fierro B
Department of Clinical Neuroscience, University of Palermo, Palermo, Italy.
Neurocase. 2010 Jun;16(3):267-72. doi: 10.1080/13554790903456191. Epub 2010 Jan 25.
Previous studies of auditory hallucinations in schizophrenia found that the hallucinations were reduced by the application of transcranial magnetic stimulation (rTMS). Here we describe a case of traumatic brain injury associated with continuous music hallucinations. An MRI scan showed a structural lesion of the right temporal pole and a PET scan indicated a hyperactive area of the posterior right temporal lobe. We hypothesized that rTMS applied to the right temporal area would reduce this activity and the corresponding hallucinations. The patient's music hallucinations were significantly reduced by rTMS treatment. A PET scan following treatment also indicated that rTMS treatment reduced brain activity in the right temporal lobe. This case provides initial evidence that rTMS may be a successful treatment of syndromes associated with hyperactive brain areas.
先前关于精神分裂症幻听的研究发现，经颅磁刺激（rTMS）可减少幻听。在此，我们描述一例与持续性音乐幻觉相关的创伤性脑损伤病例。磁共振成像（MRI）扫描显示右侧颞极有结构性病变，正电子发射断层扫描（PET）显示右侧颞叶后部有一个活跃区域。我们推测，对右侧颞区施加rTMS会降低该区域的活动及相应的幻觉。rTMS治疗使患者的音乐幻觉显著减少。治疗后的PET扫描也表明，rTMS治疗降低了右侧颞叶的脑活动。该病例提供了初步证据，表明rTMS可能是治疗与脑区活跃相关综合征的成功方法。
