Storch G A, Anderson L J, Park C S, Tsou C, Dohner D E
Edwin Mallinckrodt Department of Pediatrics, Washington University, St. Louis, Missouri.
J Infect Dis. 1991 Apr;163(4):858-61. doi: 10.1093/infdis/163.4.858.
Antigenic analysis using monoclonal antibodies and genomic analysis using ribonuclease protection was done on 47 isolates of group A respiratory syncytial virus (RSV) recovered from children in St. Louis during four RSV seasons. Antigenic analysis identified four subgroups; of the three that included more than one member, those designated A/2 and A/2V had characteristic ribonuclease protection patterns. A third subgroup, A/4, exhibited more extensive genomic heterogeneity, but all isolates were distinguishable from those in subgroups A/2 and A/2V. Individual RSV epidemic seasons included isolates representing multiple subgroups of group A and multiple intrasubgroup variants, in addition to isolates from group B. Isolates that were indistinguishable by either antigenic or genomic analysis were present in more than one epidemic season. The subgroups may represent parallel evolutionary lineages, whose relevance to RSV immunity and pathogenesis requires further study.
在四个呼吸道合胞病毒（RSV）流行季节，对从圣路易斯的儿童中分离出的47株A组呼吸道合胞病毒（RSV）进行了使用单克隆抗体的抗原分析和使用核糖核酸酶保护法的基因组分析。抗原分析确定了四个亚组；在包含多个成员的三个亚组中，指定为A/2和A/2V的亚组具有特征性的核糖核酸酶保护模式。第三个亚组A/4表现出更广泛的基因组异质性，但所有分离株都与A/2和A/2V亚组的分离株不同。除了B组的分离株外，各个RSV流行季节还包括代表A组多个亚组和多个亚组内变体的分离株。在不止一个流行季节中存在通过抗原或基因组分析无法区分的分离株。这些亚组可能代表平行的进化谱系，其与RSV免疫和发病机制的相关性需要进一步研究。
