School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Org Lett. 2010 Mar 5;12(5):1016-9. doi: 10.1021/ol100024r.
A phytochemical investigation of the fruits of Schisandra arisanensis has yielded a novel triterpenoid, arisandilactone A (1). Compound 1 has an unprecedented skeleton having a 5/5/7/5/8/5-fused hexacyclic ring system. The structure of 1 was elucidated by spectroscopic methods, especially 2D NMR techniques (COSY, HMQC, HMBC, and NOESY) and was confirmed by X-ray crystallographic analysis. A plausible biosynthetic pathway for 1 is also discussed.
五味子属植物果实的植物化学研究得到了一种新型三萜类化合物，阿里桑内酯 A（1）。化合物 1 具有前所未有的骨架，具有 5/5/7/5/8/5 稠合的六环体系。通过光谱方法，特别是 2D NMR 技术（COSY、HMQC、HMBC 和 NOESY）阐明了 1 的结构，并通过 X 射线晶体学分析得到了证实。还讨论了 1 的可能生物合成途径。
