五味子属植物红毛五味子叶和茎的化学成分。

Chemical constituents from the leaves and stems of Schisandra rubriflora.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.

出版信息

J Nat Prod. 2010 Feb 26;73(2):221-5. doi: 10.1021/np900849y.

DOI:10.1021/np900849y

PMID:20146529

Abstract

Six new nortriterpenoids, schirubridilactones A-F (1-6), as well as 14 known compounds, were isolated from the leaves and stems of Schisandra rubriflora. The structures of 1-6 were elucidated on the basis of spectroscopic methods including HSQC, HMBC, (1)H-(1)H COSY, and ROESY NMR experiments. The relative stereochemistry of 1 was confirmed through single-crystal X-ray analysis. In addition, compounds 1-6 showed anti-HIV-1 activity with EC(50) values in the range 14.3-80.8 microg/mL and selectivity indices in the range 2.2-9.0.

摘要

从五味子的叶和茎中分离得到了 6 个新的三萜类化合物，即石竹定醇 A-F（1-6），以及 14 个已知化合物。基于包括 HSQC、HMBC、（1）H-（1）H COSY 和 ROESY NMR 实验在内的光谱方法，阐明了 1-6 的结构。通过单晶 X 射线分析确定了 1 的相对立体化学。此外，化合物 1-6 表现出抗 HIV-1 活性，EC（50）值范围为 14.3-80.8μg/mL，选择性指数范围为 2.2-9.0。