State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
J Nat Prod. 2010 Feb 26;73(2):221-5. doi: 10.1021/np900849y.
Six new nortriterpenoids, schirubridilactones A-F (1-6), as well as 14 known compounds, were isolated from the leaves and stems of Schisandra rubriflora. The structures of 1-6 were elucidated on the basis of spectroscopic methods including HSQC, HMBC, (1)H-(1)H COSY, and ROESY NMR experiments. The relative stereochemistry of 1 was confirmed through single-crystal X-ray analysis. In addition, compounds 1-6 showed anti-HIV-1 activity with EC(50) values in the range 14.3-80.8 microg/mL and selectivity indices in the range 2.2-9.0.
从五味子的叶和茎中分离得到了 6 个新的三萜类化合物，即石竹定醇 A-F（1-6），以及 14 个已知化合物。基于包括 HSQC、HMBC、（1）H-（1）H COSY 和 ROESY NMR 实验在内的光谱方法，阐明了 1-6 的结构。通过单晶 X 射线分析确定了 1 的相对立体化学。此外，化合物 1-6 表现出抗 HIV-1 活性，EC（50）值范围为 14.3-80.8μg/mL，选择性指数范围为 2.2-9.0。
