School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Org Lett. 2011 Feb 4;13(3):446-9. doi: 10.1021/ol102772j. Epub 2010 Dec 22.
A novel triterpenoid, schinarisanlactone A (1), was isolated from the fruits of Schisandra arisanensis. Compound 1 possesses an unprecedented skeleton having a 5/7/7/5/7/5/6/5-fused octacyclic ring system. The structure of 1 was determined by 2D NMR techniques (COSY, HMQC, HMBC, and NOESY) and was confirmed by X-ray crystallographic analysis. Schinarisanlactone A (1) exhibited significant anti-HIV activity.
一种新型的三萜类化合物，五味子甲素 A（1），从五味子的果实中分离得到。化合物 1 具有一个前所未有的骨架，具有一个 5/7/7/5/7/5/6/5-稠合的八环体系。1 的结构通过二维 NMR 技术（COSY、HMQC、HMBC 和 NOESY）确定，并通过 X 射线晶体学分析得到证实。五味子甲素 A（1）表现出显著的抗 HIV 活性。
