Department of Epidemiology and Population Health, Tropical Epidemiological Group, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
Expert Rev Vaccines. 2010 Feb;9(2):209-22. doi: 10.1586/erv.09.161.
The bacillus Calmette-Guérin (BCG) vaccine, initially developed to provide protection against TB, also protects against leprosy; and the magnitude of this effect varies. Previous meta-analyses did not provide a summary estimate of the efficacy due to the heterogeneity of the results. We conducted a meta-analysis of published data including recently published studies (up to June 2009) to determine the efficacy of BCG protection on leprosy and to investigate whether age at vaccination, clinical form, number of doses, type of study, the latitude of study area and year of publication influence the degree of efficacy and explain the variation. In the light of the results, we argue for more emphasis on the role of BCG vaccination in leprosy control and research.
卡介苗（BCG）疫苗最初是为预防结核病而开发的，也能预防麻风病；其预防效果的大小有所不同。由于结果存在异质性，以前的荟萃分析未能提供其疗效的综合估计值。我们对已发表的数据进行了荟萃分析，其中包括最近发表的研究（截至 2009 年 6 月），以确定 BCG 对麻风病的保护作用，并调查疫苗接种年龄、临床形式、接种剂量、研究类型、研究区域的纬度和发表年份是否影响疗效，并解释变异的原因。根据研究结果，我们主张更加重视 BCG 疫苗在麻风病控制和研究中的作用。
