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免疫学。类风湿关节炎中的纵火犯。

Immunology. Arsonists in rheumatoid arthritis.

机构信息

Department of Medicine, University of Utah, Salt Lake City, UT 84112, USA.

出版信息

Science. 2010 Jan 29;327(5965):528-9. doi: 10.1126/science.1185869.

DOI:10.1126/science.1185869
PMID:20110488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4130562/
Abstract

Inflammation associated with rheumatoid arthritis is stoked by platelets, expanding their roles into the immune system.

摘要

与类风湿性关节炎相关的炎症是由血小板引起的，这扩大了它们在免疫系统中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6e/4130562/a177fdceaa25/nihms610030f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6e/4130562/a177fdceaa25/nihms610030f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c6e/4130562/a177fdceaa25/nihms610030f1.jpg

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1
Immunology. Arsonists in rheumatoid arthritis.免疫学。类风湿关节炎中的纵火犯。
Science. 2010 Jan 29;327(5965):528-9. doi: 10.1126/science.1185869.
2
Platelets amplify inflammation in arthritis via collagen-dependent microparticle production.血小板通过胶原依赖性微粒生成在关节炎中放大炎症反应。
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3
Microparticle-induced release of B-lymphocyte regulators by rheumatoid synoviocytes.类风湿性滑膜细胞通过微粒诱导释放B淋巴细胞调节因子。
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Characterization of cell-derived microparticles in synovial fluid and plasma of patients with rheumatoid arthritis.类风湿关节炎患者滑液和血浆中细胞来源的微粒的特征。
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[Detection of interleukin 1 activity in synovial fluid in rheumatoid arthritis and osteoarthritis].[类风湿性关节炎和骨关节炎患者滑液中白细胞介素1活性的检测]
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[Th17 cells].[辅助性T细胞17]
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Adv Exp Med Biol. 1999;467:565-70. doi: 10.1007/978-1-4615-4709-9_70.

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本文引用的文献

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Platelets amplify inflammation in arthritis via collagen-dependent microparticle production.血小板通过胶原依赖性微粒生成在关节炎中放大炎症反应。
Science. 2010 Jan 29;327(5965):580-3. doi: 10.1126/science.1181928.
2
PMNs facilitate translocation of platelets across human and mouse epithelium and together alter fluid homeostasis via epithelial cell-expressed ecto-NTPDases.中性粒细胞促进血小板跨人及小鼠上皮细胞的转运，并通过上皮细胞表达的胞外核苷三磷酸二磷酸酶共同改变液体稳态。
J Clin Invest. 2008 Nov;118(11):3682-92. doi: 10.1172/JCI35874. Epub 2008 Oct 16.
3
Signal-dependent protein synthesis by activated platelets: new pathways to altered phenotype and function.
肺部免疫反应和炎症性肺病中的血小板。
Physiol Rev. 2016 Oct;96(4):1211-59. doi: 10.1152/physrev.00038.2015. Epub 2016 Aug 3.
4
Pathogenic role of platelets in rheumatoid arthritis and systemic autoimmune diseases. Perspectives and therapeutic aspects.血小板在类风湿关节炎和全身性自身免疫性疾病中的致病作用。观点与治疗方面。
Saudi Med J. 2016 Apr;37(4):354-60. doi: 10.15537/smj.2016.4.14768.
5
Human xylosyltransferases--mediators of arthrofibrosis? New pathomechanistic insights into arthrofibrotic remodeling after knee replacement therapy.人类木糖基转移酶——关节纤维化的介质？膝关节置换治疗后关节纤维化重塑的新病理机制见解。
Sci Rep. 2015 Jul 28;5:12537. doi: 10.1038/srep12537.
6
LPS stimulation of purified human platelets is partly dependent on plasma soluble CD14 to secrete their main secreted product, soluble-CD40-Ligand.脂多糖对纯化的人血小板的刺激部分依赖于血浆可溶性CD14来分泌其主要分泌产物可溶性CD40配体。
BMC Immunol. 2015 Jan 31;16(1):3. doi: 10.1186/s12865-015-0067-2.
7
Platelet function beyond hemostasis and thrombosis.血小板功能不仅仅涉及止血和血栓形成。
Curr Opin Hematol. 2013 Sep;20(5):451-6. doi: 10.1097/MOH.0b013e32836344d3.
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Platelets as cellular effectors of inflammation in vascular diseases.血小板作为血管疾病炎症的细胞效应物。
Circ Res. 2013 May 24;112(11):1506-19. doi: 10.1161/CIRCRESAHA.113.300512.
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Blood. 2012 Oct 11;120(15):e60-72. doi: 10.1182/blood-2012-04-423525. Epub 2012 Aug 17.
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Platelets: active players in the pathogenesis of arthritis and SLE.血小板：关节炎和系统性红斑狼疮发病机制中的活跃参与者。
Nat Rev Rheumatol. 2012 Sep;8(9):534-42. doi: 10.1038/nrrheum.2012.118. Epub 2012 Aug 7.
活化血小板的信号依赖性蛋白质合成：改变表型和功能的新途径。
Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):s17-24. doi: 10.1161/ATVBAHA.107.160218.
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Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles.血小板介导的适应性免疫调节：血小板衍生膜囊泡对CD154信号的独特传递
Blood. 2008 May 15;111(10):5028-36. doi: 10.1182/blood-2007-06-097410. Epub 2008 Jan 15.
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Platelet microparticles are heterogeneous and highly dependent on the activation mechanism: studies using a new digital flow cytometer.血小板微粒具有异质性，且高度依赖于激活机制：使用新型数字流式细胞仪的研究
Cytometry A. 2007 Jan;71(1):38-45. doi: 10.1002/cyto.a.20354.
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Elevated levels of platelet microparticles are associated with disease activity in rheumatoid arthritis.血小板微粒水平升高与类风湿关节炎的疾病活动相关。
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Br J Haematol. 2001 Nov;115(2):451-9. doi: 10.1046/j.1365-2141.2001.03101.x.
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Cytokine pathways and joint inflammation in rheumatoid arthritis.类风湿关节炎中的细胞因子通路与关节炎症
N Engl J Med. 2001 Mar 22;344(12):907-16. doi: 10.1056/NEJM200103223441207.