Department of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Curr Opin Hematol. 2013 Sep;20(5):451-6. doi: 10.1097/MOH.0b013e32836344d3.
The platelet paradigm that is well established in hemostasis and thrombosis can be extended to other disease states. A consideration for some major health issues, such as inflammation, cancer, infection, and neuroscience, and how platelet function impacts the pathophysiology of each clinical situation is provided.
Decades of research and knowledge of platelet function exist and the same is true for inflammation and cancer. The literature is full of platelet biology overlapping into other, nonthrombotic disease states. However, major gaps exist that prevent a complete mechanistic understanding of platelet function in these other diseases. Although much of the overlap provides antidotal relationships, future studies will likely uncover novel pathophysiological pathways that are highly relevant to human diseases.
Recent findings in four major disease areas, inflammation, cancer, infection, and neuroscience, are described, with current literature linking the disease to platelet function. The availability of antiplatelet therapies, such as aspirin, exists and future consideration can be given as to whether antiplatelet therapy is potentially beneficial or harmful as the mechanisms of platelet involvement are better defined.
止血和血栓形成中已确立的血小板模式可扩展到其他疾病状态。本文考虑了一些主要健康问题，如炎症、癌症、感染和神经科学，以及血小板功能如何影响每种临床情况的病理生理学。
几十年来，人们对血小板功能的研究和认识不断深入，对炎症和癌症也是如此。文献中充满了血小板生物学与其他非血栓性疾病状态的重叠。然而，存在着重大的差距，阻碍了对这些其他疾病中血小板功能的完整机制理解。尽管大部分重叠提供了对症关系，但未来的研究可能会发现与人类疾病高度相关的新的病理生理学途径。
本文描述了炎症、癌症、感染和神经科学这四个主要疾病领域的最新发现，并结合现有文献将这些疾病与血小板功能联系起来。已经有抗血小板治疗药物，如阿司匹林，存在，随着对血小板参与机制的更好定义，可以考虑抗血小板治疗是否具有潜在的益处或危害。
