血小板作为血管疾病炎症的细胞效应物。
Platelets as cellular effectors of inflammation in vascular diseases.
机构信息
Department of Medicine and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
出版信息
Circ Res. 2013 May 24;112(11):1506-19. doi: 10.1161/CIRCRESAHA.113.300512.
Abstract
Platelets are chief effector cells in hemostasis. In addition, they are multifaceted inflammatory cells with functions that span the continuum from innate immune responses to adaptive immunity. Activated platelets have key thromboinflammatory activities in a variety of vascular disorders and vasculopathies. Recently identified inflammatory and immune activities provide insights into the biology of these versatile blood cells that are directly relevant to human vascular diseases.
摘要
血小板是止血的主要效应细胞。此外，它们还是具有多种功能的炎症细胞，其功能涵盖了从先天免疫反应到适应性免疫的连续谱。活化的血小板在多种血管疾病和血管病变中具有关键的血栓炎症活性。最近发现的炎症和免疫活性为这些多功能血细胞的生物学提供了深入了解，这些生物学与人类血管疾病直接相关。
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