CARDIA 研究中的被动吸烟暴露与循环类胡萝卜素。
Passive smoke exposure and circulating carotenoids in the CARDIA study.
机构信息
Center for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, USA.
出版信息
Ann Nutr Metab. 2010;56(2):113-8. doi: 10.1159/000277662. Epub 2010 Jan 29.
BACKGROUND/AIMS: Our objective was to assess associations between passive smoke exposure in various venues and serum carotenoid concentrations.
METHODS
CARDIA is an ongoing longitudinal study of the risk factors for subclinical and clinical cardiovascular disease. At baseline in 1985/1986, serum carotenoids were assayed and passive smoke exposure inside and outside of the home and diet were assessed by self-report. Our analytic sample consisted of 2,633 black and white non-smoking adults aged 18-30 years.
RESULTS
Greater total passive smoke exposure was associated with lower levels of the sum of the three provitamin A carotenoids, alpha-carotene, beta-carotene, and beta-cryptoxanthin (-0.048 nmol/l per hour of passive smoke exposure, p = 0.001), unassociated with lutein/zeaxanthin, and associated with higher levels of lycopene (0.027 nmol/l per hour of passive smoke exposure, p = 0.010) after adjustment for demographics, diet, lipid profile, and supplement use. Exposure in both home and non-home spaces was also associated with lower levels of the provitamin A carotenoid index.
CONCLUSION
Cross-sectionally, in 1985/86, passive smoke exposure in various venues was associated with reduced levels of provitamin A serum carotenoids.
背景/目的：我们的目的是评估在各种场所接触被动吸烟与血清类胡萝卜素浓度之间的关联。
方法
CARDIA 是一项正在进行的关于亚临床和临床心血管疾病危险因素的纵向研究。在 1985/1986 年的基线调查中，通过自我报告评估了血清类胡萝卜素、家庭内外的被动吸烟暴露情况和饮食。我们的分析样本由 2633 名年龄在 18-30 岁的不吸烟的黑人和白人非吸烟者组成。
结果
总被动吸烟暴露量越大，三种维生素 A 前体类胡萝卜素（α-胡萝卜素、β-胡萝卜素和β-隐黄质）的总和水平越低（每小时被动吸烟暴露 0.048 毫摩尔/升，p=0.001），与叶黄素/玉米黄质无关，与番茄红素水平升高相关（每小时被动吸烟暴露 0.027 毫摩尔/升，p=0.010），调整了人口统计学、饮食、血脂谱和补充剂使用情况后。家庭内外的暴露也与维生素 A 前体类胡萝卜素指数水平降低有关。
结论
在 1985/86 年的横断面研究中，各种场所的被动吸烟暴露与血清类胡萝卜素中维生素 A 前体水平降低有关。
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