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挪威北部沿海地区人群饮食中与全氟化合物相关的预测因子及其血浆浓度。

Dietary predictors and plasma concentrations of perfluorinated compounds in a coastal population from northern Norway.

机构信息

Department of Community Medicine, University of Tromsø, 9037 Tromsø, Norway.

出版信息

J Environ Public Health. 2009;2009:268219. doi: 10.1155/2009/268219. Epub 2010 Jan 6.

Abstract

Dietary intake, age, gender, and body mass index were investigated as possible predictors of perfluorinated compounds in a study population from northern Norway (44 women and 16 men). In addition to donating a blood sample, the participants answered a detailed questionnaire about diet and lifestyle. Perfluorooctane sulfonate (PFOS) (29 ng/mL), perfluorooctanoate (PFOA) (3.9 ng/mL), perfluorohexane sulfonate (PFHxS) (0.5 ng/mL), perfluorononanoate (PFNA) (0.8 ng/mL), and perfluoroheptane sulfonate (PFHpS) (1.1 ng/mL) were detected in more than 95% of all samples. Of the dietary items investigated, fruit and vegetables significantly reduced the concentrations of PFOS and PFHpS, whereas fatty fish to a smaller extent significantly increased the levels of the same compounds. Men had significantly higher concentrations of PFOS, PFOA, PFHxS, and PFHpS than women. There were significant differences in PFOS isomer pattern between genders, with women having the largest proportion of linear PFOS. PFOS, PFHxS, and PFHpS concentrations also increased with age.

摘要

在一项来自挪威北部的研究人群(44 名女性和 16 名男性)中,研究人员调查了饮食摄入、年龄、性别和体重指数等因素,以探究其是否为全氟化合物的潜在预测因子。除了捐献血液样本外,参与者还详细回答了关于饮食和生活方式的问卷。在超过 95%的所有样本中,均检测到了全氟辛烷磺酸(PFOS)(29ng/mL)、全氟辛酸(PFOA)(3.9ng/mL)、全氟己烷磺酸(PFHxS)(0.5ng/mL)、全氟壬酸(PFNA)(0.8ng/mL)和全氟庚烷磺酸(PFHpS)(1.1ng/mL)。在所调查的饮食项目中,水果和蔬菜显著降低了 PFOS 和 PFHpS 的浓度,而脂肪鱼在较小程度上显著增加了这两种化合物的水平。男性的 PFOS、PFOA、PFHxS 和 PFHpS 浓度显著高于女性。不同性别之间的 PFOS 异构体模式存在显著差异,女性的线性 PFOS 比例最大。PFOS、PFHxS 和 PFHpS 的浓度也随年龄增长而增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e7e/2810450/8b77b3b1d8fb/JEPH2009-268219.001.jpg

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