Department of Community Medicine, University of Tromsø, 9037 Tromsø, Norway.
Environ Sci Technol. 2010 Jul 1;44(13):5225-32. doi: 10.1021/es100224q.
This study was undertaken to assess the impact of self-reported dietary habits and lifestyle on the plasma concentration of selected perfluorinated compounds (PFCs) in a representative group of 315 middle-aged Norwegian women (48-62 years of age). Perfluorooctane sulfonate (PFOS; median: 20 ng/mL), perfluorooctanoate (PFOA; 4.4 ng/mL), perfluorohexane sulfonate (PFHxS; 1.0 ng/mL), and perfluorononanoate (PFNA; 0.81 ng/mL) were detected in more than 90% of the plasma samples. By using multivariate data analysis, women who ate fish or "fish eaters" (high consumers of fish and shellfish) were identified as having increased plasma concentrations of PFOS, PFNA, and PFHxS. Younger women with a larger household and a "western" diet consisting of rice, pasta, water, white and red meat, chocolate, snacks, and pastries had lower concentrations of the same compounds. No specific food cluster was associated with increased PFOA concentrations, indicating that the dietary impact on PFOA concentrations was different from that of the other investigated PFCs. This study confirms that the total diet is a major contributor to human body burdens of selected PFCs, but the identification of dietary predictors is highly dependent on the dietary habits within the population studied due to the ubiquitous presence of PFCs in many kinds of food.
本研究旨在评估饮食习惯和生活方式对 315 名挪威中年女性（48-62 岁）血浆中选定全氟化合物（PFCs）浓度的影响。在超过 90%的血浆样本中检测到全氟辛烷磺酸（PFOS；中位数：20ng/mL）、全氟辛酸（PFOA；4.4ng/mL）、全氟己烷磺酸（PFHxS；1.0ng/mL）和全氟壬酸（PFNA；0.81ng/mL）。通过多元数据分析，发现食用鱼类或“鱼类食用者”（鱼类和贝类的大量消费者）的女性其血浆中 PFOS、PFNA 和 PFHxS 浓度升高。家庭规模较大且饮食“西化”（包括米饭、意大利面、水、白肉和红肉、巧克力、零食和糕点）的年轻女性这些化合物的浓度较低。没有特定的食物群与 PFOA 浓度的升高有关，这表明饮食对 PFOA 浓度的影响与其他研究的 PFCs 不同。本研究证实，全人饮食是人体中某些 PFCs 负荷的主要来源，但由于 PFCs 普遍存在于许多种食物中，因此饮食预测因子的确定高度依赖于所研究人群的饮食习惯。
