Capriotti J A, Pelletier J S, Shah M, Caivano D M, Turay P, Ritterband D C
The New York Eye and Ear Infirmary, New York, NY, USA.
Int Ophthalmol. 2010 Dec;30(6):637-40. doi: 10.1007/s10792-010-9348-1. Epub 2010 Jan 29.
The microbial etiology of infectious corneal ulceration in Sierra Leone has been investigated. Patients either presenting to district health centers or encountered on rural surveillance expeditions with suspected infectious ulcerative keratitis were recruited into the study. Infectious corneal ulceration was defined as clinical evidence of corneal infection with epithelial defect with or without hypopyon. Cultures were obtained in a standard fashion and subsequent microbial analysis performed on all specimens. Seventy-three (73) cases of suspected infectious ulcerative keratitis were obtained between January 2005 and January 2006. The most commonly isolated organisms from microbial cultures of infected eyes were Gram-negative bacteria (45.2%), Gram-positive bacteria (37.0%), and fungal species (35.6%). Mixed bacterial and fungal organisms were isolated from ten eyes (13.7%) and no organisms were isolated from four eyes (5.5%). There is a high incidence of Gram-negative and fungal ulcerative keratitis in the population studied in Sierra Leone. Empirical therapy for corneal ulceration in this region should be aimed towards treatment of bacterial, fungal, and mixed infections.
塞拉利昂感染性角膜溃疡的微生物病因已得到研究。研究招募了到地区卫生中心就诊或在农村监测考察中遇到的疑似感染性溃疡性角膜炎患者。感染性角膜溃疡被定义为伴有或不伴有前房积脓的角膜感染且有上皮缺损的临床证据。以标准方式获取培养物，并对所有标本进行后续微生物分析。2005年1月至2006年1月期间共获得73例疑似感染性溃疡性角膜炎病例。感染眼睛的微生物培养物中最常分离出的微生物是革兰氏阴性菌（45.2%）、革兰氏阳性菌（37.0%）和真菌（35.6%）。从10只眼睛（13.7%）中分离出混合细菌和真菌微生物，4只眼睛（5.5%）未分离出微生物。在塞拉利昂所研究的人群中，革兰氏阴性菌和真菌性溃疡性角膜炎的发病率很高。该地区角膜溃疡的经验性治疗应针对细菌、真菌和混合感染。
