Department of Neurology, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Oncol Res. 2009;18(4):133-9. doi: 10.3727/096504009790217380.
FXYD3, interacting with Na+/K+-ATPase, is considered a cell surface regulator modulating the function of ion pumps and ion channels. The FXYD3 gene was originally cloned from murine mammary tumors and then from human breast tumors. However, no study of FXYD3 has been carried out in gliomas; therefore, we examined FXYD3 expression in gliomas and its clinicopathological significance. FXYD3 expression was immunohistochemically examined in 71 primary gliomas, along with 37 matched adjacent normal brain samples and 8 recurred gliomas. The frequency of strong FXYD3 expression was higher in the primary tumors in either unmatched (p = 0.046) or matched cases (p = 0.02), compared to normal brain tissue. FXYD3 expression was significantly more increased in females than males (p = 0.01), and in multiple site gliomas than single sites (p = 0.02). There was no difference of FXYD3 expression regarding age, tumor location, size, histological type, and tumor grade (p > 0.05). The results suggest that FXYD3 expression may be involved in glioma development, especially in multiple gliomas and female patients.
FXYD3 与 Na+/K+-ATPase 相互作用，被认为是一种细胞表面调节剂，可调节离子泵和离子通道的功能。FXYD3 基因最初是从小鼠乳腺肿瘤和人乳腺肿瘤中克隆出来的。然而，在神经胶质瘤中尚未进行 FXYD3 的研究；因此，我们检测了神经胶质瘤中 FXYD3 的表达及其临床病理意义。我们用免疫组化法检测了 71 例原发性神经胶质瘤、37 例配对的正常脑组织和 8 例复发的神经胶质瘤中 FXYD3 的表达。与正常脑组织相比，无论是在不配对的病例（p = 0.046）还是配对的病例（p = 0.02）中，原发性肿瘤中 FXYD3 强表达的频率更高。FXYD3 的表达在女性中明显高于男性（p = 0.01），在多部位神经胶质瘤中高于单部位（p = 0.02）。FXYD3 的表达与年龄、肿瘤部位、大小、组织学类型和肿瘤分级无关（p > 0.05）。结果表明，FXYD3 的表达可能参与了神经胶质瘤的发生，尤其是在多部位神经胶质瘤和女性患者中。
