Lv Xiong-Wen, Li Jun, Jin Yong, Zhang Lei, Wang Jian-Qing
School of Pharmacy, Anhui Medical University, Hefei 230032, China.
Zhong Yao Cai. 2009 Oct;32(10):1568-71.
To study the effects and its mechanisms of total flavonoids of Litsea coreana (TFLC) on insulin resistance (IR) in rats with hyperlipidemia.
The rats were fed with high fat emulsion to make IR models. The effects of TFLC on the state of impaired glucose tolerance (IGT), fasting serum glucose (FSG), fasting serum insulin (FINS), fasting serum lipids (TC, TG, LDL-C, HDL-C), free fatty acid (FFA) and Leptin were observed,and the index of insulin sensitivity (ISI) was calculated.
TFLC could significantly improve the state of IGT and depress the level of FSG, FINS, TC, TG, LDL-C, FFA and leptin of model rats, which could also increase the content of HDL-C and ISI significantly and enhance the sensitivity of insulin.
TFLC has obvious effects on increasing insulin sensitivity and improving the insulin resistance in rats with hyperlipidemia,which may contribute to the regulating effects on the disturbance of lipid metabolism and the decrease of leptin level.
研究毛叶木姜子总黄酮（TFLC）对高脂血症大鼠胰岛素抵抗（IR）的影响及其作用机制。
用高脂乳剂喂养大鼠制备IR模型。观察TFLC对葡萄糖耐量受损（IGT）状态、空腹血糖（FSG）、空腹血清胰岛素（FINS）、空腹血脂（总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇）、游离脂肪酸（FFA）和瘦素的影响，并计算胰岛素敏感性指数（ISI）。
TFLC可显著改善模型大鼠的IGT状态，降低其FSG、FINS、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、FFA和瘦素水平，还可显著提高高密度脂蛋白胆固醇含量和ISI，增强胰岛素敏感性。
TFLC对提高高脂血症大鼠胰岛素敏感性、改善胰岛素抵抗有明显作用，可能与调节脂质代谢紊乱及降低瘦素水平有关。
