Center of Internal Medicine and Dermatology, Charité University Medicine Berlin, Berlin, Germany.
Exp Dermatol. 2010 May;19(5):401-5. doi: 10.1111/j.1600-0625.2009.01060.x. Epub 2010 Jan 25.
Emerging evidence arising from interdisciplinary research supports the occurrence of communication axes between organs, such as the brain-gut or brain-skin axis. The latter is employed in response to stress challenge, along which neurogenic skin inflammation and hair growth inhibition is mediated. We now show that ingestion of a Lactobacillus strain in mice dampens stress-induced neurogenic skin inflammation and the hair growth inhibition. In conclusion, we are introducing a hypothesis, encouraged by our pilot observations and resting upon published prior evidence from the literature, which amalgamates previously proposed partial concepts into a new, unifying model, i.e. the gut-brain-skin axis. This concept suggests that modulation of the microbiome by deployment of probiotics can not only greatly reduce stress-induced neurogenic skin inflammation but even affect a very complex cutaneous phenomenon of (mini-) organ transformation, i.e. hair follicle cycling. These observations raise the intriguing prospect that feeding of just the right kind of bacteria can exert profound beneficial effects on skin homoeostasis, skin inflammation, hair growth and peripheral tissue responses to perceived stress.
新出现的跨学科研究证据支持器官之间存在通讯轴，例如脑-肠或脑-皮肤轴。后者用于应对压力挑战，通过它介导神经源性皮肤炎症和毛发生长抑制。我们现在表明，在小鼠中摄入一种乳杆菌菌株可抑制应激引起的神经源性皮肤炎症和毛发生长抑制。总之，我们正在提出一个假设，该假设受到我们的初步观察结果的鼓舞，并基于文献中已发表的先前证据，将以前提出的部分概念合并到一个新的统一模型中，即肠道-大脑-皮肤轴。这个概念表明，通过使用益生菌来调节微生物组不仅可以大大减轻应激引起的神经源性皮肤炎症，甚至可以影响（微小）器官转化的非常复杂的皮肤现象，即毛囊循环。这些观察结果提出了一个有趣的前景，即喂养合适种类的细菌可以对皮肤稳态、皮肤炎症、毛发生长以及外周组织对感知到的压力的反应产生深远的有益影响。
